Is the Survival of Memory B Cells Dependent on the Persistence of Antigen?
The immunisation of chimaeras constructed by transferring kappa allotype-marked thoracic duct B cells from donors primed with DNP-haemocyanin (DNP-MSH) into irradiated (femoral bone marrow shielded) recipients elicits high serum levels of anti-DNP antibodies lasting for at least 6 months (1). The majority of this antibody derives from the donor population even though this comprises only 10-20% of the total B cell pool at this time (1). Continued antibody production for such long periods may be the consequence of secretion by long-lived plasma cells in the bone marrow (2) but it seems more likely to result from repeated stimulation of B cells within memory clones.
KeywordsHost Response Thoracic Duct Soluble Antigen Donor Population Spider Crab
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