Is the Survival of Memory B Cells Dependent on the Persistence of Antigen?

  • David Gray
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)


The immunisation of chimaeras constructed by transferring kappa allotype-marked thoracic duct B cells from donors primed with DNP-haemocyanin (DNP-MSH) into irradiated (femoral bone marrow shielded) recipients elicits high serum levels of anti-DNP antibodies lasting for at least 6 months (1). The majority of this antibody derives from the donor population even though this comprises only 10-20% of the total B cell pool at this time (1). Continued antibody production for such long periods may be the consequence of secretion by long-lived plasma cells in the bone marrow (2) but it seems more likely to result from repeated stimulation of B cells within memory clones.


Host Response Thoracic Duct Soluble Antigen Donor Population Spider Crab 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    D Gray, ICM MacLennan and PJL Lane. Eur. J. Immunol. 16 641 (1986).PubMedCrossRefGoogle Scholar
  2. 2.
    F Ho, JE Lortan, ICM MacLennan and M Khan. Eur. J. Immunol. 16 1297 (1986).PubMedCrossRefGoogle Scholar
  3. 3.
    TE Mandel, RP Phipps, A Abbot and JG Tew. Immunol. Rev. 53 29 (1980).PubMedCrossRefGoogle Scholar
  4. 4.
    D Gray. This volume.Google Scholar
  5. 5.
    JG Tew, RP Phipps and TE Mandel. Immunol. Rev. 53 175 (1980).PubMedCrossRefGoogle Scholar
  6. 6.
    O Gray, manuscript submitted.Google Scholar
  7. 7.
    J Sprent and A Basten. Cell. Immunol. 7 40 (1973).PubMedCrossRefGoogle Scholar
  8. 8.
    BA Askonas, AR Williamson and BEG Wright. Proc. Nat. Acad, Sci. 67 1398 (1970).CrossRefGoogle Scholar
  9. 9.
    BA Askonas and AR Williamson. Eur. J. Immunol. 2 487 (1972).PubMedCrossRefGoogle Scholar
  10. 10.
    I.C.M MacLennan and D Gray. Immunol. Rev. 91 61 (1986).PubMedCrossRefGoogle Scholar
  11. 11.
    JI Krieger, SF Grammer, HM Grey and RW Chesnut. J. Immunol. 135 2937 (1985).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • David Gray
    • 1
  1. 1.Basel Institute for ImmunologyBaselSwitzerland

Personalised recommendations