Is the Survival of Memory B Cells Dependent on the Persistence of Antigen?

  • David Gray
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)


The immunisation of chimaeras constructed by transferring kappa allotype-marked thoracic duct B cells from donors primed with DNP-haemocyanin (DNP-MSH) into irradiated (femoral bone marrow shielded) recipients elicits high serum levels of anti-DNP antibodies lasting for at least 6 months (1). The majority of this antibody derives from the donor population even though this comprises only 10-20% of the total B cell pool at this time (1). Continued antibody production for such long periods may be the consequence of secretion by long-lived plasma cells in the bone marrow (2) but it seems more likely to result from repeated stimulation of B cells within memory clones.


Host Response Thoracic Duct Soluble Antigen Donor Population Spider Crab 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    D Gray, ICM MacLennan and PJL Lane. Eur. J. Immunol. 16 641 (1986).PubMedCrossRefGoogle Scholar
  2. 2.
    F Ho, JE Lortan, ICM MacLennan and M Khan. Eur. J. Immunol. 16 1297 (1986).PubMedCrossRefGoogle Scholar
  3. 3.
    TE Mandel, RP Phipps, A Abbot and JG Tew. Immunol. Rev. 53 29 (1980).PubMedCrossRefGoogle Scholar
  4. 4.
    D Gray. This volume.Google Scholar
  5. 5.
    JG Tew, RP Phipps and TE Mandel. Immunol. Rev. 53 175 (1980).PubMedCrossRefGoogle Scholar
  6. 6.
    O Gray, manuscript submitted.Google Scholar
  7. 7.
    J Sprent and A Basten. Cell. Immunol. 7 40 (1973).PubMedCrossRefGoogle Scholar
  8. 8.
    BA Askonas, AR Williamson and BEG Wright. Proc. Nat. Acad, Sci. 67 1398 (1970).CrossRefGoogle Scholar
  9. 9.
    BA Askonas and AR Williamson. Eur. J. Immunol. 2 487 (1972).PubMedCrossRefGoogle Scholar
  10. 10.
    I.C.M MacLennan and D Gray. Immunol. Rev. 91 61 (1986).PubMedCrossRefGoogle Scholar
  11. 11.
    JI Krieger, SF Grammer, HM Grey and RW Chesnut. J. Immunol. 135 2937 (1985).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • David Gray
    • 1
  1. 1.Basel Institute for ImmunologyBaselSwitzerland

Personalised recommendations