FDC-Iccosome Mediated Antigen Delivery to Germinal Center B Cells, Antigen Processing and Presentation to T Cells
Antigen trapped by follicular dendritic cells (FDC) is retained for long periods as intact molecules (1). An antigen must be internalized, partially degraded and reexpressed on the surface of an antigen presenting cell to be recognized by T cells (2). Consequently, it was difficult to explain how antigen retained by FDC could be presented to T cells, which are required for germinal center (GC) development (3) and can be demonstrated in GCs (4,5). Recently, antigen specific B cells were shown to process and present antigen in a highly efficient manner in vitro (6-8). Germinal center B cells have the requisite features of good antigen presenting cells, i.e., they are metabolically active, rich in la, and include cells specific for the FDC-trapped antigen. Thus, GC B cells could present antigen obtained from FDC to GC T cells.
KeywordsImmune Complex Germinal Center Follicular Dendritic Cell Popliteal Lymph Node Endocytic Vesicle
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