Transport of Immune Complexes from the Subcapsular Sinus into the Lymph Node Follicles of the Rat

  • E. W. A. Kamperdijk
  • E. A. Döpp
  • C. D. Dijkstra
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)


Immune complexes localize in lymphoid follicles of different lym-phoid organs. It has been shown that immune complex trapping in lymphoid follicles depends on the presence of complement factor C3 (1,2). The complexes are retained in follicular centers for a long time, although they may be replaced gradually by new complexes from the circulation (3).Trapping and retaining of immune complexes by follicular dendritic cells (FDC) may play an important role in the generation of immunological memory, feedback inhibition of the immune response or in both of these processes (4).


Immune Complex Mouse Lymph Node Lymphoid Follicle Horse Radish Peroxidase Follicular Dendritic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • E. W. A. Kamperdijk
    • 1
  • E. A. Döpp
    • 1
  • C. D. Dijkstra
    • 1
  1. 1.Department of Cell Biology, Medical FacultyFree UniversityMC AmsterdamThe Netherlands

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