Immunohistochemical Study on Cultured FDC-C Enriched Lymphoid Cell Populations
The follicular dendritic cell-clusters (FDC-C), which are obtained by mild enzymic digestion from lymph follicles, are now considered as the structural minimum units of the germinal centers in situ (1, 2). One isolated FDC forms a globular structure, engulfing 8 to 9 germinal center B cells. Cultured FDC-C exhibit an accessory function to lymphoid cell proliferation but reduce B-cell differentiation (3). To investigate this accessory function morphologically, we tried to clear the cellular phenomenons happening in the cultured FDC-C enriched populations, especially inside and at the periphery of the FDC-C, which an immunohistochemical method and electron microscopy.
KeywordsLymphoid Cell Germinal Center Nurse Cell Lymph Follicle Accessory Function
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