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Immunohistochemical Study on Cultured FDC-C Enriched Lymphoid Cell Populations

  • R. Tsunoda
  • N. Cormann
  • E. Heinen
  • F. Lesage
  • C. Kinet-Denoel
  • L. J. Simar
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)

Abstract

The follicular dendritic cell-clusters (FDC-C), which are obtained by mild enzymic digestion from lymph follicles, are now considered as the structural minimum units of the germinal centers in situ (1, 2). One isolated FDC forms a globular structure, engulfing 8 to 9 germinal center B cells. Cultured FDC-C exhibit an accessory function to lymphoid cell proliferation but reduce B-cell differentiation (3). To investigate this accessory function morphologically, we tried to clear the cellular phenomenons happening in the cultured FDC-C enriched populations, especially inside and at the periphery of the FDC-C, which an immunohistochemical method and electron microscopy.

Keywords

Lymphoid Cell Germinal Center Nurse Cell Lymph Follicle Accessory Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • R. Tsunoda
    • 1
  • N. Cormann
    • 1
  • E. Heinen
    • 1
  • F. Lesage
    • 1
  • C. Kinet-Denoel
    • 1
  • L. J. Simar
    • 1
  1. 1.Institute of Human HistologyUniversity of LiègeLiègeBelgium

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