Heterogeneity in the Expression of B-Cell Antigen in Non-Hodgkin’s Lymphoma

  • D. B. Jones
  • K. Moore
  • D. H. Wright
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)


The value of monoclonal antibodies (MoAbs) for the identification of neoplastic B-cells is now undisputed. Studies of normal B-cell populations with large series of MoAbs have demonstrated tha distinct markers are acquired and lost during ontogeny.I,Z Workshops on human leucocyte differentiating antigens have described a universal system for MoAb classification, MoAbs falling into the same cluster of differentiation, or CD group, bind to the same B-cell monoclonal antigen but may bind to different epitopes on that molecule. 3 The majority of pan-B reagents identify the bulk of B-cell malignancies, although the efficiency of detection varies in different histolgical types of tumour and with different CD specificities.4,5,6 In this presentation we have reviewed the performance of a range of B-cell antibodies in our routine diagnostic profiles. We report on variation in the staining obtained with different reagents and also present new data on the gfficacy of two locally produced antibodies, WR147 and WR178 in the diagnosis of B-non-Hodgkin’s lymphoma (B-NHL).


Lymphoplasmacytic Lymphoma Leucocyte Typing Lineage Antigen Follicle Centre Cell CD22 MoAb 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • D. B. Jones
    • 1
  • K. Moore
    • 2
  • D. H. Wright
    • 1
  1. 1.University Department of PathologySouthampton General HospitalSouthamptonUK
  2. 2.University Department of Regional Immunology LaboratorySouthampton General HospitalSouthamptonUK

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