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The Poly-Ig Receptor — Functional Aspects of Secretory Component Expression

  • P. Brandtzaeg
  • D. Kvale
  • L. M. Sollid
  • P. S. Thrane
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)

Abstract

Secretory tissues are quantitatively the most important mediator organ of humoral immunity — with the gut as the major contributor. There are about 1010 Ig-producing cells per metre of human small bowel (20). Most of these immunocytes produce J-chain-containing dimers or larger polymers of IgA (21). Polymeric IgA (plgA) can be transported through the crypt epithelium along with pentameric IgM by combining with a pIg receptor protein called the “secretory component” or SC (19). More IgA is translocated to the gut lumen as secretory IgA (SIgA) every day than the total daily production of IgG, which is approximately 30 mg/kg (27). The gut epithelium is responsible for most of the external IgA transport as the human bile contributes only about 1 mg/kg/day to the luminal IgA pool (27).

Keywords

Secretory Component Secretory Epithelium Human Intestinal Epithelial Cell Efferent Limb Secretory Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    K. Bjerke and P. Brandtzaeg, Lack of relation between expression of HLA-DR and secretory component (SC) in follicle-associated epithelium of human Peyer’s patches, submitted (1987).Google Scholar
  2. 2.
    P. Brandtzaeg, Structure, synthesis and external transfer of mucosal immunoglobulins, Ann. Immunol. (Inst. Pasteur) 124C: 417 (1973).Google Scholar
  3. 3.
    P. Brandtzaeg, Two types of IgA immunocytes in man, Nature, New Biol. 243: 142 (1973).Google Scholar
  4. 4.
    P. Brandtzaeg, Mucosal and glandular distribution of immunoglobulin components. Immunohistochemistry with a cold ethanol-fixation technique, Immunology 26: 1101 (1974).PubMedGoogle Scholar
  5. 5.
    P. Brandtzaeg, Mucosal and glandular distribution of immunoglobulin components. Differential localization of free and bound SC in secretory epithelial cells, J. Immunol. 112: 1553 (1974).PubMedGoogle Scholar
  6. 6.
    P. Brandtzaeg, Characteristics of SC-Ig complexes formed in vitro, Adv. Exp. Med. Biol. 45: 87 (1974).PubMedGoogle Scholar
  7. 7.
    P. Brandtzaeg, Immunochemical studies on free and bound J chain of human IgA and IgM, Scand. J. Immuno1. 4: 439 (1975).CrossRefGoogle Scholar
  8. 8.
    P. Brandtzaeg, Purification of J chain after mild reduction of human immunoglobulins, Scand. J. Immunol. 4: 309 (1975).PubMedCrossRefGoogle Scholar
  9. 9.
    P. Brandtzaeg, Blocking effect of J chain and J-chain antibody on the binding of secretory component to human IgA and IgM, Scand. J. Immunol. 4: 837 (1975).PubMedGoogle Scholar
  10. 10.
    P. Brandtzaeg, Human secretory immunoglobulin M. An immunochemical and immunohistochemical study, Immunology 29: 559 (1975).PubMedGoogle Scholar
  11. 11.
    P. Brandtzaeg, Human secretory component — IV. Aggregation and fragmentation of free secretory component, Immunochemistry 12: 877 (1975).PubMedCrossRefGoogle Scholar
  12. 12.
    P. Brandtzaeg, Complex formation between secretory component and human immunoglobulins related to their content of J chain, Scand. J. Immunol. 5: 411 (1976).PubMedCrossRefGoogle Scholar
  13. 13.
    P. Brandtzaeg, Human secretory component. VI. Immunoglobulin-binding properties, Immuno chemistry 14: 179 (1977).CrossRefGoogle Scholar
  14. 14.
    P. Brandtzaeg, Immunohistochemical studies on various aspects of glandular immunoglobulin transport in man, Histochem. J. 9: 553 (1977).PubMedCrossRefGoogle Scholar
  15. 15.
    P. Brandtzaeg, Polymeric IgA is complexed with secretory component (SC) on the surface of human intestinal epithelial cells, Scand. J. Immunol. 8: 39 (1978).PubMedCrossRefGoogle Scholar
  16. 16.
    P. Brandtzaeg, Immune functions of human nasal mucosa and tonsils in health and disease, pp. 28–95, in: “Immunology of the Lung and Upper Respiratory Tract,” J. Bienenstock, ed., McGraw-Hill, New York (1984).Google Scholar
  17. 17.
    P. Brandtzaeg, Cells producing immunoglobulins and other immune factors in human nasal mucosa, Protids Biol. Fluids 32: 363 (1985).Google Scholar
  18. 18.
    P. Brandtzaeg, Research in gastrointestinal immunology: state of the art, Scand. J. Gastroenterol. 20 (Suppl. 114): 137 (1985).CrossRefGoogle Scholar
  19. 19.
    P. Brandtzaeg, Role of J chain and secretory component in receptor-mediated glandular and hepatic transport of immunoglobulins in man, Scand. J. Immunol. 22: 111 (1985).PubMedCrossRefGoogle Scholar
  20. 20.
    P. Brandtzaeg and K. Baklien, Immunohistochemical studies of the formation and epithelial transport of immunoglobulins in normal and diseased human intestinal mucosa, Scand. J. Gastroenterol 11 (Suppl. 36): 1 (1976).Google Scholar
  21. 21.
    P. Brandtzaeg and F. R. Korsrud, Significance of different J chain profiles in human tissues: generation of IgA and IgM with binding site for secretory component is related to the J chain expressing capacity of the total local immunocyte population, including IgG and IgD producing cells, and depends on the clinical state of the tissue. Clin. Exp. Immunol. 58: 709 (1984).PubMedGoogle Scholar
  22. 22.
    P. Brandtzaeg and H. Prydz, Direct evidence for an integrated function of J chain and secretory component in epithelial transport of immunoglobulins, Nature 311: 71 (1984).PubMedCrossRefGoogle Scholar
  23. 23.
    P. Brandtzaeg and T. O. Rognum, Evaluation of nine different fixatives. 1. Preservation of immunoglobulin isotypes, J chain, and secretory component in human tissues, Pathol. Res. Pract. 179: 250 (1984).PubMedCrossRefGoogle Scholar
  24. 24.
    P. Brandtzaeg, I. Fjellanger, and S. T. Gjeruldsen, Human secretory immunoglobulins. I. Salivary secretions from individuals with normal or low levels of serum immunoglobulins, Scand. J. Haemato1. Suppl. 12, pp. 1–83 (1970).Google Scholar
  25. 25.
    W. R. Brown, Y. Isobe, and P. K. Nakane, Studies on translocation of immunoglobulins across intestinal epithelium. II. Immunoelectron-microscopic localization of immunoglobulins and secretory component in human intestinal mucosa, Gastroenterology 71: 985 (1976).PubMedGoogle Scholar
  26. 26.
    J. R. Carlson and R. L. Owen, Structure and functional role of Peyer’s patches, pp. 21–40, in: “Immunopathology of the Small Intestine,” M. N. March, ed., John Wiley & Sons, Chichester (1987).Google Scholar
  27. 27.
    D. L. Delacroix, “The human immunoglobulin A system: its vascular compartment,” pp.1–111, Thesis, Universite Catholique de Louvain, European Medical Press, Brugge (1985).Google Scholar
  28. 28.
    D. L. Delacroix and J.-P. Vaerman, Function of the human liver in IgA homeostasis in plasma, Ann. N.Y. Acad. Sci. 409: 383 (1983).PubMedCrossRefGoogle Scholar
  29. 29.
    H. Eiffert, E. Quentin, J. Decker, S. Hillemeir, M. Hufschmidt, D. Klingmuller, M. H. Weber, and N. Hilschmann, Die Primärstruktur der menschlichen freien Sekretkomponente und die Anordnung der Disulfidbrücken, Hoppe-Seyler’s Z. Physiol. Chem. 365: 1489 (1984).PubMedCrossRefGoogle Scholar
  30. 30.
    T. Eskeland and P. Brandtzaeg, Does J chain mediate the combination of 19S IgM and dimeric IgA with the secretory component rather than being necessary for their polymerization?, Immunochemistry 11: 161 (1974).PubMedCrossRefGoogle Scholar
  31. 31.
    S. Frutiger, G. J. Hughes, W. C. Hanly, M. Kingzette, and J. C. Jaton, The amino-terminal domain of rabbit secretory component is responsible for noncovalent binding to immunoglobulin A dimers, J. Biol. Chem. 261: 16673 (1986).PubMedGoogle Scholar
  32. 32.
    R. Gebhart and H. Robenek, Ligand-dependent redistribution of the IgA receptor on cultured rat hepatocytes and its disturbance by cytochalasin B, J. Histochem. Cytochem. 35: 301 (1987).CrossRefGoogle Scholar
  33. 33.
    C. Geneste, S. Iscaki, R. Mangalo, and J. Pillot, Both Fcoc domains of human IgA are involved in in vitro interaction between secretory component and dimeric IgA, Immunol. Letters 13: 221 (1986).CrossRefGoogle Scholar
  34. 34.
    C. Geneste, R. Mangalo, S. Iscaki, and J. Pillot, Human secretory component. IV. Antigenic regions involved in in vitro binding to dimeric IgA, Immunol. Letters 13: 121 (1986).CrossRefGoogle Scholar
  35. 35.
    M. R. Goodman, D. W. Link, W. I. Brown, and P. K. Nakane, Ultrastructural evidence of transport of secretory IgA across bronchial epithelium, Am. Rev. respir. Dis. 123: 115 (1981).PubMedGoogle Scholar
  36. 36.
    A. O. Grubb, Quantitation of J chain in human biological fluids by a simple immunochemical procedure, Acta. Med. Scand. 204: 453 (1978).PubMedCrossRefGoogle Scholar
  37. 37.
    H. Haimoto, H. Nagura, M. Imaizumi, K. Watanabe, and S. Iijima, Immunoelectron-microscopic study on the transport of secretory IgA in the lower respiratory tract and alveoli, Virchows Arch. A (Pathol. Anat). 404: 369 (1984).CrossRefGoogle Scholar
  38. 38.
    L. Å. Hanson and P. Brandtzaeg, The mucosal defense system, pp. 137–162, in: “Immunological Disorders in Infants and Children,” E. R. Stiehem and W. A. Fulginiti, eds., Saunders, Philadelphia (1980).Google Scholar
  39. 39.
    J. Jos, F. Labbe, B. Geny, and C. Griscelli, Immunoelectron-microscopic localization of immunoglobulin A and secretory component in jejunal mucosa from children with coeliac disease, Scand. J. Immunol. 9: 441 (1979).PubMedCrossRefGoogle Scholar
  40. 40.
    F. R. Korsrud and P. Brandtzaeg, Characterization of epithelial elements in human major salivary glands by functional markers: localization of amylase, lactoferrin, lysozyme, secretory component, and secretory immunoglobulins by paired immunofluorescence staining, J. Histochem. Cytochem. 30: 657 (1982).PubMedCrossRefGoogle Scholar
  41. 41.
    M. E. Koshland, The coming of age of the immunoglobulin J chain, Ann. Rev. Immunol. 3: 425 (1985).CrossRefGoogle Scholar
  42. 42.
    J. P. Kraehenbuhl, L. Racine, and R. E. Galardy, Localization of secretory IgA, secretory component, and a heavy chain in the mammary gland of lactating rabbits by immunoelectron microscopy, Ann. N.Y. Acad. Sci. 254: 190 (1975).PubMedCrossRefGoogle Scholar
  43. 43.
    L. Kühn and J. P. Kraehenbuhl, Role of secretory component, a secreted glycoprotein, in the specific uptake of IgA dimer by epithelial cells, J. Biol. Chem. 254: 11072 (1979).PubMedGoogle Scholar
  44. 44.
    L. Kühn and J. P. Kraehenbuhl, Interaction of rabbit secretory component with rabbit IgA dimer, J. Biol. Chem. 254: 11066 (1979).PubMedGoogle Scholar
  45. 45.
    L. C. Kühn and J. P. Kraehenbuhl, The membrane receptor for polymeric immunoglobulin is structurally related to secretory component. Isolation and characterization of membrane secretory component from rabbit liver and mammary gland, J. Biol. Chem. 256: 12490 (1981).PubMedGoogle Scholar
  46. 46.
    D. Kvale, D. Lövhaug, L. M. Sollid, and P. Brandtzaeg, Tumour necrosis factor-α upregulates expression of secretory component, the epithelial receptor for polymeric immunoglobulins, submitted (1987).Google Scholar
  47. 47.
    J. M. Larkin, E. S. Sztul, and G. E. Palade, Phosphorylation of the rat hepatic polymeric IgA receptor, Proc. Natl. Acad. Sci. USA 83: 4759 (1986).PubMedCrossRefGoogle Scholar
  48. 48.
    J. Mestecky and J. R. McGhee, Immunoglobulin A (IgA): molecular and cellular interactions involved in IgA biosynthesis and immune response, Advan. Immuno1. 40: 153 (1987).CrossRefGoogle Scholar
  49. 49.
    K. E. Mostov and G. Blobel, A transmembrane precursor of secretory component. The receptor for transcellular transport of polymeric immunoglobulins, J. Biol. Chem. 257: 11816 (1982).PubMedGoogle Scholar
  50. 50.
    K. E. Mostov and J. L. Deitcher, Polymeric immunoglobulin receptor expressed in MDCK cells transcytoses IgA, Cell 46: 613 (1986).PubMedCrossRefGoogle Scholar
  51. 51.
    K. E. Mostov, A. de Bruyn Kops, and D. L. Deitcher, Deletion of the cytoplasmic domain of the polymeric immunoglobulin receptor prevents basolateral localization and endocytosis, Cell 47: 359 (1986).PubMedCrossRefGoogle Scholar
  52. 52.
    K. E. Mostov, M. Friedlander, and G. Blobel, The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains, Nature 308: 37 (1984).PubMedCrossRefGoogle Scholar
  53. 53.
    K. E. Mostov, J. P. Kraehenbuhl, and G. Blobel, Receptor-mediated transcellular transport of immunoglobulin: synthesis of secretory component as multiple and larger transmembrane forms, Proc. Natl. Acad. Sci. USA 77: 7257 (1980).PubMedCrossRefGoogle Scholar
  54. 54.
    H. Nagura, P. K. Nakane, and W. R. Brown, Secretory component in immunoglobulin deficiency: an immunoelectron microscopic study of intestinal epithelium, Seand. J. Immunol. 12: 359 (1980).CrossRefGoogle Scholar
  55. 55.
    K. Pfizenmaier, P. Scheurich, C. Schluter, and M. Kronke, Tumor necrosis factor enhances HLA-A, B, C, and HLA-DR gene expression in human tumor cells, J. Immunol. 138: 975 (1987).PubMedGoogle Scholar
  56. 56.
    R. S. H. Pumphrey, Computer models of the human immunoglobulins. Binding sites and molecular interactions, Immunol. Today 7: 206, (1986).CrossRefGoogle Scholar
  57. 57.
    M. E. Poger and M. E. Lamm, Localization of free and bound secretory component in human intestinal epithelial cells. A model for the assembly of secretory IgA, J. Exp. Med. 139: 629 (1974).PubMedCrossRefGoogle Scholar
  58. 58.
    N. H. Ruddle, Tumor necrosis factor and related cytokines. Immunol. Today 8: 129 (1987).CrossRefGoogle Scholar
  59. 59.
    H. Saito, T. Kasajima, and H. Nagura, An immunocytochemical study on secretory mechanisms of IgA in human pancreas, Acta Pathol. Jpn. 35: 87 (1985).PubMedGoogle Scholar
  60. 60.
    P. Scheurich, M. Kronke, C. Schluter, U. Ucer, and K. Pfizenmaier, Noncytocidal mechanisms of action of tumor necrosis factor-α on human tumor cells: enhancement of HLA gene expression synergistic with interferon-X, Immunobiology 172: 291 (1986).PubMedCrossRefGoogle Scholar
  61. 61.
    J. M. Schiff, K. J. Dorrington, and B. J. Underdown, Secretory component and immunoglobulin transport, 4th International Congress of Immunology, Abstr. No. 7.5.29 (1980).Google Scholar
  62. 62.
    J. M. Schiff, M. M. Fisher, and B. J. Underdown, Secretory component as the mucosal transport receptor: separation of physicochemically analogous human IgA fractions with different receptor-binding capacities, Molec. Immuno1. 23: 45 (1986).CrossRefGoogle Scholar
  63. 63.
    H. Scott, P. Brandtzaeg, B. G. Solheim, and E. Thorsby, Relation between HLA-DR-like antigens and secretory component (SC) in jejunal epithelium of patients with coeliac disease or dermatitis herpetiformis, Clin. Exp. Immunol. 44: 233 (1981).PubMedGoogle Scholar
  64. 64.
    W. S. Selby, L. W. Poulter, S. Hobbs, D. P. Jewell, and G. Janossy, Heterogeneity of HLA-DR. positive histiocytes in human intestinal lamina propria: a combined histochemical and immunohistological analysis, J. Clin. Pathol. 36: 379 (1983).PubMedCrossRefGoogle Scholar
  65. 65.
    D. J. Socken and B. J. Underdown, Comparison of human bovine and rabbit secretory component-immunoglobulin interactions, Immunochemistry 15: 499 (1978).PubMedCrossRefGoogle Scholar
  66. 66.
    R. Solari and J.-P. Kraehenbuhl, Biosynthesis of the IgA antibody receptor: a model for the transepithelial sorting of a membrane glycoprotein, Cell 36: 61 (1984).PubMedCrossRefGoogle Scholar
  67. 67.
    L. M. Sollid, G. Gaudernack, G. Markussen, D. Kvale, P. Brandtzaeg, and E. Thorsby, Induction of various HLA class II molecules in a human colonie adenocarcinoma cell line, Scand. J. Immuno1. 25: 175 (1987).CrossRefGoogle Scholar
  68. 68.
    L. M. Sollid, D. Kvale, P. Brandtzaeg, G. Markussen, and E. Thorsby, Interferon-δ enhances expression of secretory component, the epithelial receptor for polymeric immunoglobulins, J. Immunol. 138: 4303 (1987).PubMedGoogle Scholar
  69. 69.
    P. S. Thrane, L. M. Sollid, P. Brandtzaeg, and H. R. Haanes, Increased expression of secretory component (SC) and HLA-DR in salivary gland epithelium from patients with Sjögren’s syndrome, submitted (1987).Google Scholar
  70. 70.
    K. Vaines, P. Brandtzaeg, L. Elgjo, and R. Stave, Specific and nonspecific humoral defense factors in the epithelium of normal and inflamed gastric mucosa. Immunohistochemical localization of immunoglobulins, secretory component, lysozyme, and lactoferrin, Gastroenterology 86: 402 (1984).Google Scholar
  71. 71.
    J. Zikan, J. Novotny, T. L. Trapane, M. E. Koshland, D. W. Urry, J. C. Bennett, and J. Mestecky, Secondary structure of the immunoglobulin J chain, Proc. Natl. Acad. Sci. USA 82: 5905 (1985).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • P. Brandtzaeg
    • 1
  • D. Kvale
    • 1
  • L. M. Sollid
    • 1
  • P. S. Thrane
    • 1
  1. 1.Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute of PathologyUniversity of OsloRikshospitaletNorway

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