Both LY-1 B Cells And Conventional B Cells Make Autoantibodies to Bromelain-Treated Autologous Erythrocytes
In mice a minor subpopulation of B cells has been described which has a different phenotype and function from the majority of B cells1 2and which belongs to a separate B cell lineage3. These B cells are characterized by the expression of about 5-fold more membrane IgM and 10-fold less IgD than cells of the conventional B lineage4. In addition, many of them express a surface molecule, Ly-1 (CD5), previously thought to be present only on T cells4 5. These Ly-1 B cells occur at low frequency (1–2%) in adult spleen, are not detectable in lymph nodes or blood1, but account for up to 50% of the B cells in the peritoneal cavity3.
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