Thymus-Independent Type 2 Responses in Lymph Nodes

  • Liu Yong-Jun
  • Susan Oldfield
  • Ian C. M. MacLennan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)


Splenectomy in adult rats produces a profound and prolonged impairment of their capacity to respond to the thymus-independent type 2 (TI-2) antigen, dinitrophenylated hydroxyethyl starch (DNP-HES) but has no effect on their response to the TD antigen, DNP-haemocyanin (1). However, this impairment is not complete suggesting that some other organs have some capacity to respond to TI-2 antigens. In this study we show the ability of peripheral lymph nodes to produce limited responses to these antigens.


Marginal Zone Peripheral Lymph Node Popliteal Lymph Node Serum Antibody Response Hind Footpad 
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  1. 1.
    D. Gray, D. Chassoux, I.C.M. MacLennan, and H. Bazin Clin. exp. Immunol. 60: 70 (1985).Google Scholar
  2. 2.
    J.K. Inman. J. Immunol. 114: 704 (1975).PubMedGoogle Scholar
  3. 3.
    E. Claasen, and N. Van Rooijen. J. Histochem. & Cytoehem. 33: 840 (1985).CrossRefGoogle Scholar
  4. 4.
    A.G.E. Pearse. Histochemistry. Theoretical and Applied, vol. 1 & 2, Churchill Livingstone, Edinburgh (1968).Google Scholar
  5. 5.
    R.C. Graham, U. Lundholm, N.J. Karnovsky. J. Histochem. Cytoehem. 13: 150 (1965).CrossRefGoogle Scholar
  6. 6.
    G.D. Johnson, and E.J. Holborow. In “Handbook of Experimental Immunology”, Blackwell Scientific Publications, Oxford (1984).Google Scholar
  7. 7.
    F.G.M. Kroese, D. Opstelten, A.S. Wubbena, G.J. Deenen, J. Ater, E.H. Schwander, L. de Leij, and P. Nieuwenhuis. Adv. Exp. Med. Biol. 186: 81 (1985).PubMedGoogle Scholar
  8. 8.
    J.H. Humphrey, and D. Grennan. Eur. J. Immunol. 11: 221 (1981).PubMedCrossRefGoogle Scholar
  9. 9.
    P.J.L. Lane, D. Gray, S. Oldfield, and I.C.M. MacLennan. Eur. J. Immunol. 16: 1569 (1986).PubMedCrossRefGoogle Scholar
  10. 10.
    D.S. Kumararatne, H. Bazin, and I.C.M. MacLennan. Eur. J. Immunol. 11: 858 (1981).PubMedCrossRefGoogle Scholar
  11. 11.
    D. Gray, I.C.M. MacLennan, H. Bazin and M. Khan. Eur. J. Immunol. 12: 564 (1982).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Liu Yong-Jun
    • 1
  • Susan Oldfield
    • 1
  • Ian C. M. MacLennan
    • 1
  1. 1.Department of ImmunologyUniversity of BirminghamBirminghamUK

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