CBA/N Mice have Marginal Zone B Cells with Normal Surface Immunoglobulin Phenotype

  • Liu Yong-Jun
  • Jennifer E. Lortan
  • Susan Oldfield
  • Ian C. M. MacLennan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)


Antigens can be broadly classified into those which require T cell help to evoke an immune response and those which do not (1). However, the T cell-independent (TI) antigens can be further subdivided on the basis of time during ontogeny when they can evoke antibody respones (2). In man the TI-1 group of antigens can activate B cells in vivo before birth while TI-2 antigens fail to evoke normal responses until some months after birth. Another criterion which allows the TI-1 and TI-2 antigens to be distinguished is the relative capacity of these two groups of antigens to generate antibody responses in CBA/N mice (3). TI-1 antigens evoke responses in these mice while TI-2 antigens do not. TI-2 antigens are mostly based upon a core structure of polysaccharide. Haptens linked to polysaccharides such as Ficoll or hydroxyethyl starch, behave as TI-2 antigens.


Marginal Zone Hydroxyethyl Starch Double Immunofluorescence Double Immunofluorescence Staining Spleen Section 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Liu Yong-Jun
    • 1
  • Jennifer E. Lortan
    • 1
  • Susan Oldfield
    • 1
  • Ian C. M. MacLennan
    • 1
  1. 1.Department of ImmunologyUniversity of BirminghamBirminghamUK

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