Marginal Zone B Cells and the Localisation of Antigen on Follicular Dendritic Cells

  • S. Oldfield
  • J. E. Lortan
  • M. A. J. Hyatt
  • I. C. M. MacLennan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)


The mechanism of uptake of antigen by follicular dendritic cells (FDC) is poorly understood, but complement and preformed antibody have been shown to be necessary for this to process (1). Brown et al (2) suggested that lymphocytes may be involved in the active transport of antigen into follicles. More recent studies (3,4) have led to the suggestion that it may be marginal zone B cells which transport antigen into splenic follicles.


Immune Complex Hind Limb Marginal Zone Total Body Irradiation Follicular Dendritic Cell 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • S. Oldfield
    • 1
  • J. E. Lortan
    • 1
  • M. A. J. Hyatt
    • 1
  • I. C. M. MacLennan
    • 1
  1. 1.Department of ImmunologyThe Medical School University of BirminghamBirminghamUK

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