In Vitro Infection of Human Epidermal Langerhans Cells with HIV

  • G. Ramirez
  • L. R. Braathen
  • R. O. F. Kunze
  • H. Gelderblom
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)


Human epidermal Langerhans cells (Lc) play an important role in antigen presentation and immunoregulation in the skin (for review see ref.(1)).They carry antigens and receptors which are identical to those of classical macrophages, i.e. FcIgG, C3 and the MHC class II HLA-D/DR antigens (2,3),but also the T-cell markers CDKT6) and CD4(T4) (4–6). Remarkably, Lc exhibit 50-fold higher amounts of HLA-DR than other cells of the monocyte-macrophage lineage (7).


Human Immunodeficiency Virus Peripheral Blood Mononuclear Cell Human Immunodeficiency Virus Infection Transmitted Human Immunodeficiency Virus Autologous Serum 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • G. Ramirez
    • 1
  • L. R. Braathen
    • 2
  • R. O. F. Kunze
    • 1
  • H. Gelderblom
    • 1
  1. 1.Dept. VirologyRobert Koch Institute BundesgesundheitsamtBerlinGermany
  2. 2.Dept. Dermatol., RikshospitaletUniversity of OslowNorway

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