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In Vitro Infection of Human Epidermal Langerhans Cells with HIV

  • G. Ramirez
  • L. R. Braathen
  • R. O. F. Kunze
  • H. Gelderblom
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)

Abstract

Human epidermal Langerhans cells (Lc) play an important role in antigen presentation and immunoregulation in the skin (for review see ref.(1)).They carry antigens and receptors which are identical to those of classical macrophages, i.e. FcIgG, C3 and the MHC class II HLA-D/DR antigens (2,3),but also the T-cell markers CDKT6) and CD4(T4) (4–6). Remarkably, Lc exhibit 50-fold higher amounts of HLA-DR than other cells of the monocyte-macrophage lineage (7).

Keywords

Human Immunodeficiency Virus Peripheral Blood Mononuclear Cell Human Immunodeficiency Virus Infection Transmitted Human Immunodeficiency Virus Autologous Serum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    L.R. Braathen, S. Bjercke, and E. Thorsby. Immunbiol. 168: 301 (1984).Google Scholar
  2. 2.
    G. Stingl, E.C. Wolff-Schreiner, W.J. Pichler, F. Gschnait, W. Knapp, and K. Wolff. Nature 268: 245 (1977).PubMedCrossRefGoogle Scholar
  3. 3.
    L. Klareskog, U.M. Tjernlund, U. Forsum, and P.A. Peterson. Nature 268: 247 (1977).CrossRefGoogle Scholar
  4. 4.
    G.S. Wood, N.L. Warner, and R.A. Warnke. J. Immunol. 131: 212 (1983).PubMedGoogle Scholar
  5. 5.
    K. Wolff, and G. Stingl. J. Invest. Dermatol. 80 (suppl): 17s (1983).CrossRefGoogle Scholar
  6. 6.
    V. Groh, M. Tani, A. Harrer, K. Wolff, and G. Stingl. J. Invest, Dermatol. 86: 115 (1986).CrossRefGoogle Scholar
  7. 7.
    S. Bjercke, G. Gaudernack, and L.R. Braathen. Scand. J. Immunol. 21: 489 (1985).PubMedCrossRefGoogle Scholar
  8. 8.
    F. Wong-Staal, R.C. Gallo. Nature 317: 395 (1985).PubMedCrossRefGoogle Scholar
  9. 9.
    G. Dalgleish, P.L.C. Beverley, P.R. Clapham, D.H. Crawford, M.F. Greaves, R.A. Weiss. Nature 312: 763 (1984).PubMedCrossRefGoogle Scholar
  10. 10.
    D. Klatzmann, E. Champagne, S. Chamaret, J. Gruest, D. Guetard, T. Hercend, J.C. Gluckman, L. Montagnier. Nature 312: 767 (1984).PubMedCrossRefGoogle Scholar
  11. 11.
    J.S. McDougal, M.S. Kennedy, J.M. Sligh, S.P. Cort, A. Mawle, and J.K.A. Nicholson. Science 231: 382 (1986).PubMedCrossRefGoogle Scholar
  12. 12.
    S.M. Lederinan, J. Barasch, M. Godfrey, D. Sherman, M. Gershon, and L. Chess. Clin. Res. 34: 670A (1986)Google Scholar
  13. 13.
    D. Klatzmann, F. Barre-Sinoussi, M.T. Nugeyre, C. Dauguet, E. Vilmer, C. Griscelle, F. Brun-Vezinet, C. Rouzioux, J.C. Gluckman, J-C. Chermann, and L. Montagnier. Science 225: 59 (1984).PubMedCrossRefGoogle Scholar
  14. 14.
    J.A. Armstrong, R.L. Dawkins, and R. Home. Immunology Today 6: 121 (1985).CrossRefGoogle Scholar
  15. 15.
    D.D. Ho, T.R. Rota, M.S. Hirsch. J. Clin. Invest. 77: 1712 (1986).PubMedCrossRefGoogle Scholar
  16. 16.
    S. Gartner, P. Markovitz, D.M. Markovitz, R.F. Betts, and M. Popovic. JAMA 256: 2365 (1986).PubMedCrossRefGoogle Scholar
  17. 17.
    G.S. Wood, B.F. Burns, R.F. Dorfman, and R.A. Warnke. Am. J. Pathol. 120: 371 (1985).PubMedGoogle Scholar
  18. 18.
    D.V. Belsito, M.R. Sanchez, R.L. Baer, F. Valentine, G.J. Thorbecke. N. Engl. J. Med. 310: 1279 (1984).PubMedCrossRefGoogle Scholar
  19. 19.
    D.V. Belsito, and G.J. Thorbecke. N. Engl. J. Med. 311: 857 (1984).Google Scholar
  20. 20.
    E. Tschachler, V. Groh, M. Popovic, D.L. Mann, K. Konrad, B. Safai, L. Eron, F.D. Veronese, K. Wolff, and G. Stingl. J. Invest. Dermatol. 88: 233 (1987).PubMedCrossRefGoogle Scholar
  21. 21.
    L.R. Braathen, and E. Thorsby. Scand. J. Immunol. 11: 401 (1980).PubMedCrossRefGoogle Scholar
  22. 22.
    J.L. Cordell, B. Falini, W.N. Erder, A.K. Ghosh, Z. Abdulaziz, S. MacDonald, K.A. Pulford, H. Stein, and D.Y. Mason. J. Histochem. Cytochem. 32: 219 (1984).PubMedCrossRefGoogle Scholar
  23. 23.
    B. Volc-Platzer, G. Stingl, K. Wolff, W. Hinterberger, and W. Schnedl. N. Engl. J. Med. 310: 1123 (1984).PubMedGoogle Scholar
  24. 24.
    L.R. Braathen, E. Berle, U. Mobech-Hanssen, and E. Thorsby.Acta Dermatovener (Stockh). 60: 381 (1980)Google Scholar
  25. 25.
    L.R. Braathen, and E. Thorsby. Br. J. Dermatol. 108: 139 (1983).PubMedCrossRefGoogle Scholar
  26. 26.
    L.R. Braathen, and E. Thorsby. Scand. J. Immunol. 15: 55 (1982).PubMedCrossRefGoogle Scholar
  27. 27.
    S. Bjercke, H. Scott, L.R. Braathen, and E. Thorsby. Acta Obstet. Gynecol. Scand. 62: 585 (1983).PubMedCrossRefGoogle Scholar
  28. 28.
    H. Gelderblom, H. Reupke, T. Winkel, R. Kunze, and G. Pauli. Submitted.Google Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • G. Ramirez
    • 1
  • L. R. Braathen
    • 2
  • R. O. F. Kunze
    • 1
  • H. Gelderblom
    • 1
  1. 1.Dept. VirologyRobert Koch Institute BundesgesundheitsamtBerlinGermany
  2. 2.Dept. Dermatol., RikshospitaletUniversity of OslowNorway

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