Characterization of Cell Populations, Reappearing in the Mouse Spleen After Elimination by Liposome Encapsulated Dichloromethylene Diphosphonate: Reappearance of Marginal Zone Lymphocytes is Independent of Marginal Zone Macrophages
Macrophages in the spleen can be eliminated by treatment with liposome encapsulated dichloromethylene diphosphonate (DMDP; reviewed in ref. 1. These macrophages disappeared during the first day after intravenous injection with liposome-encapsulated DMDP, remained absent for one week and reappeared gradually in the next weeks, as studied with the aid of enzyme histochemical techniques (2). Macrophages in different compartments of the mouse spleen can now be characterized by various monoclonal antibodies (3–6).
KeywordsMarginal Zone Mouse Spleen White Pulp Single Intravenous Injection Multilamellar Liposome
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- 1.N. van Rooijen, and E. Claassen, in: ‘Liposomes as drug carriers: Trends and progress’, G. Gregoriadis, ed., John Wiley, Chichester, U.K. (1987).Google Scholar