The immune response of inbred mice against the “thymus-independent” antigen (1->3) Dextran 1355S (Dex) is genetically controlled. Congenic BALB.Ighk mice are considered to be non-responders (1). BALB/c mice (Igha) are high responders (2) with expression of anti-Dex antibodies sharing idiotopes of public (MOPC 104, J 558) and private idiotypes (3). Conventionally raised euthymic BALB/c mice, due to T cell regulation, produce predominantly IgM, but only rarely IgG anti-Dex antibodies of these idiotypes (4,5). In BALB/c nu/nu and isolator raised (germfree) BALB/c mice, however, the class switch to IgG occurs readily in all animals (4).
Spleen Cell Adoptive Transfer Inbred Mouse Class Switch High Responder
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