Impact of IgD Receptor-Positive T Cells on the Immune Response

  • R. F. Coico
  • C. Swenson
  • G. W. Siskind
  • G. J. Thorbecke
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)


IgD is present on the surface of the majority of B lymphocytes, whereas serum IgD levels are low. This has suggested to previous investigators1, that the major function of IgD is to serve as a surface receptor, but no definite biological role different from surface IgM has been found for this molecule. Investigation of the effect of IgD on immune responses was prompted by our observation that IgD-myeloma-bearing mice exhibit greatly enhanced immune responses2. We find that injections of IgD enhance antibody production and that this effect of IgD is correlated with the induction of receptors for IgD on helper T cells3. Such T cells are able to transfer immuno-augmentation to normal recipients4. It appears that “TS” cells can be induced by cross-linked IgD on the surface of B cells, and lead to enhanced: 1) primary and secondary responses, 2) 1g production of all isotypes studied, and 3) germinal center formation. The findings supporting these conclusions are reviewed below.


Germinal Center Aged Mouse Polyclonal Activation Germinal Center Formation Germinal Center Cell 
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  1. 1.
    B. Pernis. Lymphocyte membrane IgD, Immunol. Rev. 37: 210 (1977).PubMedCrossRefGoogle Scholar
  2. 2.
    B. Xue, R. Coico, D. Wallace, G.W. Siskind, B. Pernis, and G.J. Thorbecke. Physiology of IgD. IV. Enhancement of antibody production in mice bearing IgD-secreting plasmacytomas, J. Exp. Med. 159: 103 (1984).PubMedCrossRefGoogle Scholar
  3. 3.
    R.F. Coico, B. Xue, D. Wallace, B. Pernis, G.W. Siskind, and G.J. Thorbecke. T cells with receptors for IgD, Nature 316: 744 (1985).PubMedCrossRefGoogle Scholar
  4. 4.
    R.F. Coico, B. Xue, D. Wallace, G.W. Siskind, and G.J. Thorbecke.Physiology of IgD. VI. Transfer of the immuno augment ing effect of IgD wiht TS-containing helper cell populations, J. Exp. Med. 162: 1852 (1985).PubMedCrossRefGoogle Scholar
  5. 5.
    G. A. Bishop and G. Haughton. Induced differentiation of a transformed clone of Ly-1+ B cells by clonal T cells and antigen, Proc. Natl. Acad. Sci. USA 83: 7410 (1986).PubMedCrossRefGoogle Scholar
  6. 6.
    I. Berkower, H. Kawamura, L.A. Matis, and J.A. Berzofsky. T cell clones to two major T cell epitopes of myoglobin: effect of I-A/I-E restriction on epitope dominance, J. Immunol. 135: 2628 (1985).PubMedGoogle Scholar
  7. 7.
    R.F. Coico, J.A. Berzofsky, J. York-Jolley, S. Ozaki, G.W. Siskind, and G.J. Thorbecke. Physiology of IgD. VII. Induction of receptors for IgD on cloned T cells by IgD and interleukin 2, J. Immunol. 138: 4 (1987).PubMedGoogle Scholar
  8. 8.
    H. Kiyono, L.M. Mosteller-Barnum, A.M. Pitts, S.I. Williamson, S.M. Michalek, and J.R. McGhee. Isotype-specific immunoregulation. IgA-binding factors produced by Fca receptor-positive T cell hybridomas regulate IgA responses, J. Exp. Med. 161: 731 (1985).PubMedCrossRefGoogle Scholar
  9. 9.
    N.K. Jerne, A.A. Nordin, and C. Henry. The agar plaque technique for recognizing the antibody producing cells, in “Cell Bound Antibody”, Amos and Koprowsky, eds., Wistar Institute Press, Philadelphia, 109 (1963).Google Scholar
  10. 10.
    M.S. Neuberger and K. Rajewsky. Switch from hapten-specific immunoglobulin M to immunoglobulin D secretion in a hybrid mouse cell line, Proc. Natl. Acad. Sci. USA 78: 1138 (1981).PubMedCrossRefGoogle Scholar
  11. 11.
    R.F. Coico, S.R.S. Gottesman, G.W. Siskind, and G.J. Thorbecke. Physiology of IgD. VIII. Age-related decline in the capacity to generate T cells with receptors for IgD and partial reversal of the defect with IL 2, J. Immunol. 138: 2776 (1987).PubMedGoogle Scholar
  12. 12.
    F.D. Finkelman, I. Scher, J.J. Mond, J.T. Kung, and E.S. Metcalf. Polyclonal activation of the murine immune system by an antibody to IgD. I. Increase in cell size and DNA synthesis, J. Immunol. 129: 629 (1982).PubMedGoogle Scholar
  13. 13.
    F.D. Finkelman, J. Smith, N. Villacreses, and E.S. Metcalf. Polyclonal activation of the murine immune system by an antibody to IgD. VI. Influence of dose of goat anti-mouse δ chain and normal goat IgG on B lymphocyte proliferation and differentiation, Eur. J. Immunol. 15: 315 (1985).PubMedCrossRefGoogle Scholar
  14. 14.
    F.D. Finkelman, J. Smith, N. Villacreses, and E.S. Metcalf. Polyclonal activation of the murine immune system by an antibody to IgD. VII. Demonstration of the role of nonantigen-specific T help in in vivo B cell activation, J. Immunol. 133: 550 (1984).PubMedGoogle Scholar
  15. 15.
    R.F. Coico, F. Finkelman, CD. Swenson, G.W. Siskind, and G.J. Thorbecke. Exposure to crosslinked IgD induces receptors for IgD on T cells in vivo and in vitro, Proc. Natl. Acad. Sci. USA, in press (1987).Google Scholar
  16. 16.
    P.M. Allen and E.R. Unanue. Differential requirements for antigen processing by macrophages for lysozyme-specific T cell hybridomas, J. Immunol. 132: 1077 (1984).PubMedGoogle Scholar
  17. 17.
    R.G. Hoover and R.G. Lynch. Lymphocyte surface membrane imrnuno-glubulin in myeloma. II. T cells with IgA-Fc receptors are markedly increased in mice with IgA plasmacytomas, J. Immunol. 125: 1280 (1980).PubMedGoogle Scholar
  18. 18.
    R.F. Coico, B.S. Bhogal, and G.J. Thorbecke. Relationship of germinal centers in lymphoid tissue to immunologic memory. VI. Transfer of B cell memory with lymph node cells fractionated according to their receptors for peanut agglutinin, J. Immunol. 131: 2254 (1983).PubMedGoogle Scholar
  19. 19.
    C.D. Swenson, R.F. van Vollenhoven, B. Xue, G.W. Siskind, G.J. Thorbecke, and R.F. Coico. Physiology of IgD. IX. Effect of IgD on immunoglobulin production in young and old mice (submitted for publication).Google Scholar
  20. 20.
    D. Yuan. Regulation of IgM and IgD synthesis in B lymphocytes. II. Translational and post-translational events, J. Immunol. 132: 1566 (1984).PubMedGoogle Scholar
  21. 21.
    S. Kanowith-Klein, E.S. Vitetta, E.L. Korn, and R.F. Ashman. Ant ig en-induced changes in the proportion of antigen binding cells expressing IgM, IgG and IgD receptors, J. Immunol. 122: 2349 (1979).PubMedGoogle Scholar
  22. 22.
    A. Mathur, D.M. Kamat, B.G. Vanness, and R.G. Lynch. Thymus-dependent in vivo suppression of IgE synthesis in a murine IgE-secreting hybridoma, J. Immunol. in press (1987).Google Scholar
  23. 23.
    W.H. Fridman, C. Rabourdin-Combe, C. Naeuport-Sautes, and R.H. Gisler. Characterization and function of T cell Fey receptors, Immunol. Rev. 56: 51 (1981).PubMedCrossRefGoogle Scholar
  24. 24.
    M. Adachi and K. Ishizaka. IgD-binding factors from mouse T lymphocytes, Proc. Natl. Acad. Sci. USA 83: 7003 (1986).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • R. F. Coico
    • 1
  • C. Swenson
    • 1
  • G. W. Siskind
    • 1
  • G. J. Thorbecke
    • 1
  1. 1.CUNY Medical SchoolCornell University Medical College and NYU School of MedicineNew YorkUSA

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