Impact of IgD Receptor-Positive T Cells on the Immune Response
IgD is present on the surface of the majority of B lymphocytes, whereas serum IgD levels are low. This has suggested to previous investigators1, that the major function of IgD is to serve as a surface receptor, but no definite biological role different from surface IgM has been found for this molecule. Investigation of the effect of IgD on immune responses was prompted by our observation that IgD-myeloma-bearing mice exhibit greatly enhanced immune responses2. We find that injections of IgD enhance antibody production and that this effect of IgD is correlated with the induction of receptors for IgD on helper T cells3. Such T cells are able to transfer immuno-augmentation to normal recipients4. It appears that “TS” cells can be induced by cross-linked IgD on the surface of B cells, and lead to enhanced: 1) primary and secondary responses, 2) 1g production of all isotypes studied, and 3) germinal center formation. The findings supporting these conclusions are reviewed below.
KeywordsGerminal Center Aged Mouse Polyclonal Activation Germinal Center Formation Germinal Center Cell
Unable to display preview. Download preview PDF.
- 9.N.K. Jerne, A.A. Nordin, and C. Henry. The agar plaque technique for recognizing the antibody producing cells, in “Cell Bound Antibody”, Amos and Koprowsky, eds., Wistar Institute Press, Philadelphia, 109 (1963).Google Scholar
- 13.F.D. Finkelman, J. Smith, N. Villacreses, and E.S. Metcalf. Polyclonal activation of the murine immune system by an antibody to IgD. VI. Influence of dose of goat anti-mouse δ chain and normal goat IgG on B lymphocyte proliferation and differentiation, Eur. J. Immunol. 15: 315 (1985).PubMedCrossRefGoogle Scholar
- 15.R.F. Coico, F. Finkelman, CD. Swenson, G.W. Siskind, and G.J. Thorbecke. Exposure to crosslinked IgD induces receptors for IgD on T cells in vivo and in vitro, Proc. Natl. Acad. Sci. USA, in press (1987).Google Scholar
- 19.C.D. Swenson, R.F. van Vollenhoven, B. Xue, G.W. Siskind, G.J. Thorbecke, and R.F. Coico. Physiology of IgD. IX. Effect of IgD on immunoglobulin production in young and old mice (submitted for publication).Google Scholar
- 22.A. Mathur, D.M. Kamat, B.G. Vanness, and R.G. Lynch. Thymus-dependent in vivo suppression of IgE synthesis in a murine IgE-secreting hybridoma, J. Immunol. in press (1987).Google Scholar