The Involvement of T-Cells in the Stimulatory Effect of a Water-in-Oil Emulsion on the B-Cell Response

  • A. T. J. Bianchi
  • J. W. Scholten
  • B. A. Bokhout
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)


Originally the immunostimulatory effect of water-in-oil (W/O)emulsions, used as adjuvant, has been explained by depot formation resulting in a chronic stimulation of the immune system by small amounts of released antigen (1,2). Later studies by ourselves (3,4) clearly demonstrated that other mechanisms are involved also.


Nude Mouse Mouse Strain Adjuvant Effect Depot Formation Plaque Form Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Freund, J. Adv. Tubercul. Res. 7: 130 (1956)Google Scholar
  2. 2.
    Allison, A.C. and N.E. Byars. J. Immunol. Meth. 95: 157 (1986)CrossRefGoogle Scholar
  3. 3.
    Heijden, P.J. van der, B.A. Bokhout, A.T.J. Bianchi, J.W. Schöpplten and W. Stok. Immunobiol. 171: 143 (1986)CrossRefGoogle Scholar
  4. 4.
    Bokhout, B.A., A.T.J. Bianchi, Ph.J. van der Heijden, J.W. Schöppl-ten and W. Stok. Comp. Immun. Microbiol. Infect. Dis. 9: 161 (1986)CrossRefGoogle Scholar
  5. 5.
    Spitznagel, J.K. and A.C. Allison. J. Immunol. 104: 128 (1970)PubMedGoogle Scholar
  6. 6.
    Bokhout, B.A., C. van Gaalen, P.J. van der Heijden. Vet. Immunol. Immunopathol. 2: 491 (1981)CrossRefGoogle Scholar
  7. 7.
    Koch, G., B.D. Lok, A. van Oudenaren and R. Benner. J. Immunol. 128: 1479 (1982)Google Scholar
  8. 8.
    Seppälä, I.J.T. and O. Mäkela. Immunology 53: 827 (1983)Google Scholar
  9. 9.
    Flebbe, L.M. and H. Braley-Mullen. Cell. Immunol. 99: 119 (1986)PubMedCrossRefGoogle Scholar
  10. 10.
    Flebbe, L.M. and H. Braley-Mullen. Cell. Immunol. 99: 128 (1986)PubMedCrossRefGoogle Scholar
  11. 11.
    Ivars, F., G. Nyberg, D. Holmberg and A. Coutinho. J. Exp. Med. 158: 1498 (1985)CrossRefGoogle Scholar
  12. 12.
    Mongini, P.K.A., K.E. Stein and W.E. Paul. J. Exp. Med. 153: 1 (1983)CrossRefGoogle Scholar
  13. 13.
    Endres, R.O., E. Kushnir, J.W. Kappler, P. Marrack and S.C. Kinsley. J. Immunol. 130: 781 (1983)PubMedGoogle Scholar
  14. 14.
    Allison, A.C. and A.J.S. Davies. Nature 233: 330 (1971)PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • A. T. J. Bianchi
    • 1
  • J. W. Scholten
    • 1
  • B. A. Bokhout
    • 1
  1. 1.Dept. ImmunologyCentral Veterinary InstituteLelystadThe Netherlands

Personalised recommendations