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Monocyte Defect Causes Decreased Automlr in Multiple Sclerosis Patients

  • C. N. Baxevanis
  • G. J. Reclos
  • P. Arsenis
  • A. Katsiyiannis
  • N. Matikas
  • M. Papamichail
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)

Summary

We have recently demonstrated that peripheral blood monocytes from patients with multiple sclerosis (MS) have a defect in stimulating autologous and allogeneic T lymphocytes. This defect was found to correlate with disease activity. We report here that T4+ cells from MS patients proliferate weakly in the autologous mixed lymphocyte reaction (autoMLR). Furthermore, we provide direct proof that the depressed T4+ cell proliferation is due to the monocyte functional (stimulatory) defect.

Keywords

Multiple Sclerosis Multiple Sclerosis Patient Peripheral Blood Monocyte Mixed Lymphocyte Reaction Active Multiple Sclerosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • C. N. Baxevanis
    • 1
  • G. J. Reclos
    • 1
  • P. Arsenis
    • 1
  • A. Katsiyiannis
    • 1
  • N. Matikas
    • 2
  • M. Papamichail
    • 1
  1. 1.Department of ImmunologyHellenic Anticancer InstituteAthensGreece
  2. 2.Neurology DepartmentEvangelismos State HospitalAthensGreece

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