Monocyte Defect Causes Decreased Automlr in Multiple Sclerosis Patients
We have recently demonstrated that peripheral blood monocytes from patients with multiple sclerosis (MS) have a defect in stimulating autologous and allogeneic T lymphocytes. This defect was found to correlate with disease activity. We report here that T4+ cells from MS patients proliferate weakly in the autologous mixed lymphocyte reaction (autoMLR). Furthermore, we provide direct proof that the depressed T4+ cell proliferation is due to the monocyte functional (stimulatory) defect.
KeywordsMultiple Sclerosis Multiple Sclerosis Patient Peripheral Blood Monocyte Mixed Lymphocyte Reaction Active Multiple Sclerosis
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