Human Peritoneal Macrophages Enhance HLA-DR Expression in Culture and are Very Potent Stimulators of an Allogeneic Mixed Leucocyte Reaction

  • H. J. Bos
  • B. Kranenburg
  • R. H. J. Beelen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)


The expression of Major Histocompatibility Complex (MHC) class II antigens on macrophages in the rat, mouse and in the human system has been shown to be essential for antigen presentation. In both rat and mice 1a expression of peritoneal macrophages decreases after culture (1–4),but in the human system this point has been poorly investigated. In the human system almost only the adherent monocyte subpopulations have been studied for HLA-DR expression in culture. Some investigators showed an enhancement (5,6) or a more or less stable (3,7) HLA-DR expression in culture. Others even demonstrated a decrease of HLA-DR expression (8–11).


Major Histocompatibility Complex Class Continuous Ambulatory Peritoneal Dialysis Peritoneal Cell Dritic Cell Continuous Ambulatory Peritoneal Dialysis Patient 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • H. J. Bos
    • 1
  • B. Kranenburg
    • 1
  • R. H. J. Beelen
    • 2
  1. 1.Departments of Electron Microscopy, Medical FacultyFree UniversityAmsterdamThe Netherlands
  2. 2.Departments of HaematologyUniversity Hospital, Free UniversityAmsterdamThe Netherlands

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