Advertisement

Human Peritoneal Macrophages Enhance HLA-DR Expression in Culture and are Very Potent Stimulators of an Allogeneic Mixed Leucocyte Reaction

  • H. J. Bos
  • B. Kranenburg
  • R. H. J. Beelen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)

Abstract

The expression of Major Histocompatibility Complex (MHC) class II antigens on macrophages in the rat, mouse and in the human system has been shown to be essential for antigen presentation. In both rat and mice 1a expression of peritoneal macrophages decreases after culture (1–4),but in the human system this point has been poorly investigated. In the human system almost only the adherent monocyte subpopulations have been studied for HLA-DR expression in culture. Some investigators showed an enhancement (5,6) or a more or less stable (3,7) HLA-DR expression in culture. Others even demonstrated a decrease of HLA-DR expression (8–11).

Keywords

Major Histocompatibility Complex Class Continuous Ambulatory Peritoneal Dialysis Peritoneal Cell Dritic Cell Continuous Ambulatory Peritoneal Dialysis Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    D.I. Beller, and E.R. Unanue. J. Iinmunol. 126: 263 (1981).Google Scholar
  2. 2.
    W.S. Walker, R.B. Hester, and R.H.J. Beelen. Cell. Immunol. 79: 125 (1983).PubMedCrossRefGoogle Scholar
  3. 3.
    S.L. Kunkel, D.A. Campbell Jr., S.W. Chensue, and G.I. Higashi. Cell. Immunol. 99: 140 (1986).CrossRefGoogle Scholar
  4. 4.
    E.W.A. Kamperdijk, M.A.M. Verdaasdonk, and R.H.J. Beelen. Immunology 19: 3 (1987).Google Scholar
  5. 5.
    S. Becker, and A. Takiguchi. Macrophage Biology, p. 455. Alan R. Liss Inc., New York (1985).Google Scholar
  6. 6.
    G.S. Firestein, and N.J. Zwaifler. Cell. Immunol. 104: 343 (1986).CrossRefGoogle Scholar
  7. 7.
    D.M. Glover, D. Brownstein, S. Barchett, A. Larsen, and C.B. Wilson. Immunol. 61: 195 (1987).Google Scholar
  8. 8.
    G. Gaudernack, and S. Bjercke. Scand. J. Immunol. 21: 493 (1985).PubMedCrossRefGoogle Scholar
  9. 9.
    T.A. Gonwa, and J.D. Stobo. J. Clin. Invest. 74: 859 (1985).CrossRefGoogle Scholar
  10. 10.
    M.R. Sztein, P.S. Skeg, H.M. Johnson, and J.J. Oppenheim. J. Clin. Invest. 73: 556 (1984).PubMedCrossRefGoogle Scholar
  11. 11.
    G. Kaplan, and G. Gaudernack. J. Exp. Med. 156: 1101 (1982).PubMedCrossRefGoogle Scholar
  12. 12.
    R.H.J. Beelen, M. van’ t Veer, D.M. Fluitsma, and E.C.M. Hoefsmit. J. Reticuloendothel. Soc. 24: 351 (1978).PubMedGoogle Scholar
  13. 13.
    A. Böppyum. J. Clin. Lab. Invest, (suppl.) 97: 29 (1968).Google Scholar
  14. 14.
    A. Böppyum. Scand. J. Clin. Lab. Invest, (suppl.) 145: 264 (1977).Google Scholar
  15. 15.
    H. Spits, J. Borst, M. Giphart, J. Coligan, C. Terhorst, and J.E. de Vries. Eur. J. Immunol. 14: 299 (1984).PubMedCrossRefGoogle Scholar
  16. 16.
    G.D. Keizer, J. Borst, W. Visser, R. Schwarting, J.E. de Vries, and C.G. Figdor. J. Immunol, in press (1987).Google Scholar
  17. 17.
    A. Dimitriu-Bona, G.R. Burmester, S.J. Waters, and R.J. Winchester. J. Immunol. 130: 145 (1983).PubMedGoogle Scholar
  18. 18.
    V. Quarantana, N. Tanigaki, and S. Ferrone. Immunogenet. 12: 175 (1981).CrossRefGoogle Scholar
  19. 19.
    E.C.M. Hoefsmit, I.L. Schadee, and R.H.J. Beelen. J. Histochem. Cyto-chem. 34: 633 (1986).CrossRefGoogle Scholar
  20. 20.
    M.A. Markwell, and C.F. Fox. Biochem. 17: 4807 (1978).CrossRefGoogle Scholar
  21. 21.
    W.S. Walker, R.H.J. Beelen, P.J. Buckley, S.L. Melvin, and S.E. Yen. J. Immunol. Methods. 67: 89 (1984).PubMedCrossRefGoogle Scholar
  22. 22.
    M. Mottolese, P.G. Natali, G. Atlante, A. Cavallari, F. Difilippo, and S. Ferrone. J. Immunol. 135: 200 (1985).PubMedGoogle Scholar
  23. 23.
    M.E. Lipscomb, C.R. Lyons, G. Nunez, E.J. Ball, P. Stastny, W. Vial, V. Lenn, J. Weissler, L.M. Miller, and G.B. Toews. J. Immunol. 136: 497 (1986).PubMedGoogle Scholar
  24. 24.
    W.C. van Voorhis, L.S. Hair, R.M. Steinman, and G. Kaplan. J. Exp. Med. 155: 1172 (1982).PubMedCrossRefGoogle Scholar
  25. 25.
    S. Bjercke, and G. Gaudernack. Scand. J. Immunol. 21: 501 (1985).PubMedCrossRefGoogle Scholar
  26. 26.
    S. Knight, J. Farrant, A. Byant, A.J. Edwards, S. Burmen, A. Lever, J. Clarke, and D.B. Webster. Immunology 57: 595 (1986).PubMedGoogle Scholar
  27. 27.
    G. Nunez, E.J. Bail, L.K. Meyers, and P. Stastny. In: Histocompatibility Testing (eds. E.D. Albert, M.P. Baur, and W.R. Mayr), p. 636. Springer Verlag, Berlin (1984).CrossRefGoogle Scholar
  28. 28.
    S.C. Knight, P. Fryer, S. Griffiths, and B. Harding. Immunology 61: 21 (1987).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • H. J. Bos
    • 1
  • B. Kranenburg
    • 1
  • R. H. J. Beelen
    • 2
  1. 1.Departments of Electron Microscopy, Medical FacultyFree UniversityAmsterdamThe Netherlands
  2. 2.Departments of HaematologyUniversity Hospital, Free UniversityAmsterdamThe Netherlands

Personalised recommendations