Induction of Class II MHC Antigen Expression in Rat Organs after Systemic Application of Recombinant Gamma Interferon

  • B. Steiniger
  • P. H. van der Meide
  • P. Falk
  • J. Klempnauer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)


Class II MHC antigens appear in a variety of previously negative cell types during immune reactions in vivo and may decisively contribute to antigen presentation and target cell destruction. In cell culture systems gamma interferon was identified as one of the most potent mediators inducing class II antigen expression (1). In vivo effects of gamma interferon on MHC antigen distribution have been described but have not been analyzed exhaustively (2,3). Detailed dose-response studies in experimental animals are lacking. We have thus investigated the class II MHC antigen inducing capacity of different amounts of recombinant rat gamma interferon in lymphatic and non-lymphatic organs after prolonged intravenous infusion.


Acinar Cell Gamma Interferon High Endothelial Venule Interferon Dose Recombinant Gamma Interferon 


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • B. Steiniger
    • 1
  • P. H. van der Meide
    • 2
  • P. Falk
    • 1
  • J. Klempnauer
    • 3
  1. 1.Centre of AnatomyHannover Medical SchoolGermany
  2. 2.TNO Primate CentreRijswijkNetherlands
  3. 3.Centre of SurgeryHannover Medical SchoolGermany

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