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Induction of Class II MHC Antigen Expression in Rat Organs after Systemic Application of Recombinant Gamma Interferon

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Histophysiology of the Immune System

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 237))

Abstract

Class II MHC antigens appear in a variety of previously negative cell types during immune reactions in vivo and may decisively contribute to antigen presentation and target cell destruction. In cell culture systems gamma interferon was identified as one of the most potent mediators inducing class II antigen expression (1). In vivo effects of gamma interferon on MHC antigen distribution have been described but have not been analyzed exhaustively (2,3). Detailed dose-response studies in experimental animals are lacking. We have thus investigated the class II MHC antigen inducing capacity of different amounts of recombinant rat gamma interferon in lymphatic and non-lymphatic organs after prolonged intravenous infusion.

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Author information

Authors and Affiliations

  1. Centre of Anatomy, Hannover Medical School, Germany

    B. Steiniger & P. Falk

  2. TNO Primate Centre, Rijswijk, Netherlands

    P. H. van der Meide

  3. Centre of Surgery, Hannover Medical School, Germany

    J. Klempnauer

Authors
  1. B. Steiniger
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  2. P. H. van der Meide
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  3. P. Falk
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  4. J. Klempnauer
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Editor information

Editors and Affiliations

  1. Anatomical Institute, Oslo, Norway

    Sigbjørn Fossum  & Bent Rolstad  & 

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© 1988 Plenum Press, New York

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Steiniger, B., van der Meide, P.H., Falk, P., Klempnauer, J. (1988). Induction of Class II MHC Antigen Expression in Rat Organs after Systemic Application of Recombinant Gamma Interferon. In: Fossum, S., Rolstad, B. (eds) Histophysiology of the Immune System. Advances in Experimental Medicine and Biology, vol 237. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5535-9_119

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  • DOI: https://doi.org/10.1007/978-1-4684-5535-9_119

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5537-3

  • Online ISBN: 978-1-4684-5535-9

  • eBook Packages: Springer Book Archive

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