Immunological Characteristics of Milky Spots in the Omentum of Rats

  • R. H. J. Beelen
  • I. L. Eestermans
  • E. A. Döpp
  • C. D. Dijkstra
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)


In the rat model we have clearly shown In the past that the diversity of cytochemically heterogeneous populations of macrophages is best explained by stage of maturation differentiation of cells belonging to one lineage(1) in the sequence monocyte (or exudate macrophage) — exudate-resident macrophage — resident macrophage, the dynamics being related to the state of inflammation induced (2,3). Our earlier studies on milky spots In the omentum Indicated that they are a source of the free peritoneal macrophages as judged by the maturation pattern based on morphology (4) and cytochemistry (5). Moreover, precursor cells as promonocytes may settle and proliferate in milky spots and so locally generate as a pool of monocytes and macrophages. Interestingly in the milky spots the more immature macrophages were found inside and the mature resident macrophages outside, indicating their maturation route. These results were later confirmed by others (6,7).


Mesothelial Cell Mononuclear Phagocyte Resident Macrophage Milky Spot Free Peritoneal 


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • R. H. J. Beelen
    • 1
  • I. L. Eestermans
    • 1
  • E. A. Döpp
    • 1
  • C. D. Dijkstra
    • 1
  1. 1.Department of Cell Biology, Medical FacultyFree UniversityAmsterdamThe Netherlands

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