Ontogeny of Macrophages and Dendritic Cells of the Rat

  • Christine D. Dijkstra
  • E. P. Van Rees
  • E. A. Döpp
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)


Earlier studies on the ontogeny of macrophages have demostrated that the immunological immaturity of newborn rodents is at least in part due to the immaturity of the macrophage system (1,2). In particular the capacity of macrophages to present antigen and thus induce an adequate immune respons was impaired in neonates as compared to adults (13,19,21), which appeared to be due to a low number of la-positive antigen presenting cells (15,20). A considerable number of studies are now available on the ontogenetic development of antigen presenting cells in the different lymphoid organs as thymus (10,12), gut and gut-associated tissue(17,25,26), spleen (7,11) and lymph node (24) or in cell suspensions of these organs (14,16). In these studies, the antigen presenting cells, in particular the interdigitating cells (IDC, in tissues) respectively dendritic cells (DC, in cell suspensions) were studied using either their expression of la-antigen or their antigen presenting capacity as characteristic.


Mesenteric Lymph Node White Pulp Ontogenetic Development Antigen Present Capacity Macrophage Subpopulation 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Christine D. Dijkstra
    • 1
  • E. P. Van Rees
    • 1
  • E. A. Döpp
    • 1
  1. 1.Department of Histology, Medical FacultyFree UniversityAmsterdamThe Netherlands

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