J Chain is Expressed by More IgA2-than IgA1-Producing Cells in Colonic Mucosa, but it is Reduced in Both Subclasses in Inflammatory Bowel Disease
We have recently observed a shift from the normal predominance of IgA2- (1) to IgA1- producing cells in colonic mucosa from patients with ulcerative colitis (UC) and Crohn’s colitis (CC) (2). This disease-associated alteration may be of great biological importance in terms of secretory immunity. Only J-chain-containing polymeric immunoglobulins(pIg), such as dimeric IgA (pIgA) and pentameric IgM will bind to secretory component (SC) which functions as a pig transport receptor on secretory epithelial cells (3). In this study the capacity of mucosal IgA1- and IgA2-producing cells for plgA formation was examined by paired immunofluorescence staining for subclass and J chain, both in normal and inflamed colonic tissue specimens.
KeywordsUlcerative Colitis Colonic Mucosa Secretory Component Secretory Epithelial Cell Heavy Chain Constant Region
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