Mucosal Priming Alters Pathogenesis of Rift Valley Fever
The concept of a common Mucosal Immune System implies that enteric priming would be effective in initiating secretory immunity in local and non-intestinal mucosal sites. If this1, 2 tenet also applies to protective immunity, enteric immunization could be utilized to advantage in vaccination against viruses that may impinge upon the conjunctiva, nasopharynx, respiratory, and gastrointestinal tracts. Recent studies showed that parenteral immunization with non-replicating viral antigens was ineffective in protecting rodents from aerosol challenge with virulent virus, although similarly vaccinated animals were completely protected from parenteral challenge with the same dose of virus3. Live attenuated viral vaccines elicited protective immunity for either route of challenge regardless of the route of immunization. The present studies were conducted in order to ascertain the optimum route of immunization for respiratory immunity and the effects of mucosal VS peripheral immunization on Rift Valley fever Virus (RVFV) pathogenesis in mice.
KeywordsOlfactory Bulb Fulminant Hepatitis Rift Valley Fever Rift Valley Fever Virus Lateral Olfactory Tract
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