Mucosal Priming Alters Pathogenesis of Rift Valley Fever

  • Arthur O. Anderson
  • Lisa F. Snyder
  • M. Louise Pitt
  • Owen L. Wood
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)


The concept of a common Mucosal Immune System implies that enteric priming would be effective in initiating secretory immunity in local and non-intestinal mucosal sites. If this1, 2 tenet also applies to protective immunity, enteric immunization could be utilized to advantage in vaccination against viruses that may impinge upon the conjunctiva, nasopharynx, respiratory, and gastrointestinal tracts. Recent studies showed that parenteral immunization with non-replicating viral antigens was ineffective in protecting rodents from aerosol challenge with virulent virus, although similarly vaccinated animals were completely protected from parenteral challenge with the same dose of virus3. Live attenuated viral vaccines elicited protective immunity for either route of challenge regardless of the route of immunization. The present studies were conducted in order to ascertain the optimum route of immunization for respiratory immunity and the effects of mucosal VS peripheral immunization on Rift Valley fever Virus (RVFV) pathogenesis in mice.


Olfactory Bulb Fulminant Hepatitis Rift Valley Fever Rift Valley Fever Virus Lateral Olfactory Tract 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    S. W. Craig, and J. J. Cebra, J, Exp, Med, 134: 188, (1971).CrossRefGoogle Scholar
  2. 2.
    M. R. McDermott, and J. Bienenstock, J. Immunol, 122: 1892, (1979)PubMedGoogle Scholar
  3. 3.
    P. B. Jahrling, and E. H. Stephenson, J, Clin. Microbiol, 19: 429, (1984).Google Scholar
  4. 4.
    A. O. Anderson, T. T. MacDonald, and D. H. Rubin, Int, J, Immunother, 1: 107, (1985).Google Scholar
  5. 5.
    D. H. Rubin, A. O. Anderson, and D. Lucis, Ann, N.Y. Acad. Sci. 409: 866, (1983).CrossRefGoogle Scholar
  6. 6.
    N. Pierce, and J. B. J. Sacci, Infect, Immun, 44: 469, (1984).Google Scholar
  7. 7.
    W. S. Miller, P. Demchak, C. R. Rosenberger, J. W. Dominik, and J. L. Bradshaw, Amer, J. Hygiene, 77;114, (1963).Google Scholar
  8. 8.
    J.M. Meegan, Trans. Roy. Soc. Trop. Med, and Hygiene, 73: 618, (1979).CrossRefGoogle Scholar
  9. 9.
    J. L. Brown, J. W. Dominik, and R. L. Morrissey, Infect. Immun. 33: 848, (1981).PubMedGoogle Scholar
  10. 10.
    R. Randall, L. N. Binn, and V. R. Harrison, J. Immunol. 93: 923, (1964).Google Scholar
  11. 11.
    H. I. Tappert, J. M. Meegan, J. M. Dalrymple, and C. J. Peters, (Submitted).Google Scholar
  12. 12.
    M. W. Chase, Proc. Soc. Exp. Biol. Med. 61: 257, (1946).PubMedGoogle Scholar
  13. 13.
    N. F. Pierce, J. Exp. Med. 148: 195, (1978).PubMedCrossRefGoogle Scholar
  14. 14.
    F. T. Koster, and N. F. Pierce, J. Immunol. 131: 115, (1983).PubMedGoogle Scholar
  15. 15.
    J. A. Fuhrman, and J. J. Cebra, J. Exp. Med. 153: 534, (1984).CrossRefGoogle Scholar
  16. 16.
    M. L. Dunkley, and A. J. Husband, Immunol. 57: 379, (1986).Google Scholar
  17. 17.
    S. C. Gautom, and J. R. Battlsto, J. Immunol. 135: 2975, (1985).Google Scholar
  18. 18.
    J. Bienenstock, (ed.), IMMUNOLOGY OF THE LUNG AND UPPER RESPIRATORY TRACTS, McGraw-Hill Book Co., (1984).Google Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Arthur O. Anderson
    • 1
  • Lisa F. Snyder
    • 1
  • M. Louise Pitt
    • 1
  • Owen L. Wood
    • 1
  1. 1.Laboratory of Respiratory and Mucosal Immunity USAMRIIDFrederickUSA

Personalised recommendations