Modulation of Histamine Secretion from Rat and Human Mast Cell Subpopulations
Mast cells are distributed throughout the connective tissues of the body where they interact with numerous environmental agents including other cells and their products, blood-bourne materials, and foreign substances that penetrate the overlying epithelia and enter subjacent connective tissue compartments. Many of these agents are capable of stimulating mast cells to release their cache of multipotent mediators. For example, antigens, macrophage (19) and T cell factors (11), vagus nerve stimulation (13) and neuropeptides (20) have all been shown to activate mast cells. Furthermore, although they are best known for their responses to allergens in immediate hypersensitivity reactions, mast cells are involved in such diverse immune and inflammatory phenomena as cell and organismal toxicity, immunoregulation, promotion of neovascularization and fibroblast proliferation (1).
KeywordsMast Cell Histamine Release Vagus Nerve Stimulation Human Basophil Histamine Secretion
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