Jejunal Epithelium of Patients with Coeliac Disease Shows Enhanced Expression of MHC Class II Subregion Products
We have previously shown that HLA class II molecules are expressed by small intestinal epithelial cells, both in control subjects with a normal mucosa (1) and in coeliac disease (CD) patients with total villous atrophy (2). CD is HLA-associated, and particularly related to DR3, DR7 (3) and DQ2 (A,5). It develops in genetically susceptible individuals because of gluten ingestion. Antigens of gluten may be presented by enterocytes to intraepithelial T cells as an initial step in the pathogenesis of CD. Class II-positive rat enterocytes have in fact been reported to perform antigen presentation (6). In this study we used a panel of monoclonal antibodies to better define the epithelial expression of class II subregion products in CD.
KeywordsSurface Epithelium Coeliac Disease Crypt Epithelium Coeliac Disease Patient Epithelial Expression
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