Differential Expression of Epithelial MHC Class II Determinants (HLA-DR, -DP, and -DQ) and Increased Class I Expression in Inflamed Salivary Glands

  • Per S. Thrane
  • Per Brandtzaeg
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)


Sjögren’s syndrome (SS) affects salivary and lacrimal glands, causing xerostomia and keratoconjunivitis. An increased number of infiltrating leukocytes are present and the glandular tissue is gradually destroyed. Increased epithelial HLA-DR expression in salivary glands from SS patients has been reported (1,2,3), but the other MHC class II subregion products(HLA-DP and -DQ) and MHC class I determinants have not been studied.


Salivary Gland Pleomorphic Adenoma Salivary Gland Tissue Salivary Gland Epithelial Cell Epithelial Expression 


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Per S. Thrane
    • 1
    • 2
  • Per Brandtzaeg
    • 1
  1. 1.Laboratory for Immunohistochemistry and Immunopathology (LIIPAT)Institute of Pathology, Medical Faculty, The National Hospital, RikshospitaletOslo 1Norway
  2. 2.Department of Oral Surgery and Oral Medicine, Dental FacultyUniversity of OsloOslo 1Norway

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