Developments in Immunosuppression The Secret to the Success of Organ Transplantation

  • Charles T. Van Buren


For centuries, surgeons have operated on patients in order to remove diseased tissues or to manage traumatic injuries. The objectives of practitioners of such an extirpative discipline became to minimize the surgical tissue loss or to adapt the patient to a regrettable but necessary disability. Only during the twentieth century has the focus of surgery expanded from ablation of disease and shifted toward the restoration of lost function by transplanting living and normally functioning tissues and organs from one individual to another. The success of clinical transplantation has been limited by the transplant surgeon’s understanding of the body’s immune response to transplanted tissues and by effective modulation of this response through suppression of the immune system. An understanding of the history of clinical immunosuppression enables one to understand both the limitations and the future of clinical organ transplantation.


Renal Allograft Allograft Survival Renal Allograft Recipient Mixed Lymphocyte Culture Thoracic Duct Lymph 
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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • Charles T. Van Buren
    • 1
  1. 1.Division of Immunology/Organ TransplantationUniversity of Texas Medical School at HoustonHoustonUSA

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