Oncogenic Viruses

  • Mario R. Escobar


This chapter begins with a brief account of the important events that have occurred during the history of viral oncology. After this is a description of the major subgroups of DNA and RNA oncogenic viruses followed by a discussion of the pathobiology and unifying features of viral oncogenesis and cell transformation. Next, there is a review of established animal models of human cancer and an examination of the most widely investigated oncogenic human viruses. Finally, the immunologic aspects of neoplasia are considered in some detail, concluding with remarks on the future perspectives in the field of viral oncology.


Herpes Simplex Virus Type Oncogenic Virus Rous Sarcoma Virus Primary Hepatocellular Carcinoma Avian Leukosis Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Temin, H. M., 1981, Nature of the provirus of Rous sarcoma. Natl. Cancer Inst. Monog. 17: 557–570.Google Scholar
  2. 2.
    Temin, H. M., and Mizutani, S., 1970, RNA-dependent DNA polymerase in virions of Rous sarcoma virus. Nature (Lond.) 226: 1211–1213.CrossRefGoogle Scholar
  3. 3.
    Baltimore, D., 1970, RNA-dependent DNA polymerase in virions of RNA tumor viruses. Nature (Land.) 226: 1209–1211.CrossRefGoogle Scholar
  4. 4.
    Green, M., 1985, Transformation and oncogenesis: DNA viruses, in: Virology ( B. N. Fields, ed.), pp. 183–234, Raven, New York.Google Scholar
  5. 5.
    Bateman, T., 1814, A Practical Synopsis of Cutaneous Diseases, 3rd ed., Longman, Hurst, Rees, Orme and Brown, London.Google Scholar
  6. 6.
    Goodpasture, E. W., and Woodruff, C. E., 1931, A comparison of the inclusion bodies of the fowlpox and molluscum contagiosum, Am. J. Pathol. 7: 1–7.PubMedGoogle Scholar
  7. 7.
    Vogt, M., and Dulbecco, R., 1960, Virus-cell interaction with a tumor producing virus, Proc. Natl. Acad. Sci. USA 46: 365–370.PubMedCrossRefGoogle Scholar
  8. 8.
    Niven, J. S. F., Armstrong, J. A., Andrews, C. H., Pereira, H. G., and Valentine, R. C., 1961, Subcutaneous “growths” in monkeys produced by a poxvirus, J. Pathol. 81: 1–14.CrossRefGoogle Scholar
  9. 9.
    Richardson, E. 1961, Progressive multifocal leukoencephalopathy, N. Engl. J. Med. 265: 815–823.PubMedCrossRefGoogle Scholar
  10. 10.
    Trentin, J. J., Yabe, Y., and Taylor, G., 1962, The quest for human cancer viruses, Science 137: 835–841.PubMedCrossRefGoogle Scholar
  11. 11.
    Epstein, M. A., Anchong, B. G., and Barr, Y. M., 1964, Virus particles in cultured lymphoblasts from Burkitt’s lymphoma, Lancet 1: 702–703.PubMedCrossRefGoogle Scholar
  12. 12.
    Pulvertaft, R. J. V., 1964, Cytology of Burkitt’s tumor (African lymphoma), Lancet 1: 238–240.PubMedCrossRefGoogle Scholar
  13. 13.
    Rawls, W. E., Tompkins, W. A. F., and Melnick, J. L., 1969, The association of herpes virus type 2 and carcinoma of the uterine cervix, Am. J. Epidemiol. 89: 547–554.PubMedGoogle Scholar
  14. 14.
    Albrecht, T., and Rapp, F., 1973, Malignant transformation of cancer embryo fibroblasts following exposure to ultraviolet-irradiated human cytomegalovirus, Virology 55: 53–61.PubMedCrossRefGoogle Scholar
  15. 15.
    zur Hausen, H., 1976, Condyloma acuminata and human genital cancer, Cancer Res. 36: 794.PubMedGoogle Scholar
  16. 16.
    Gardner, S., 1977, The new human papovaviruses: Their nature and significance, in: Recent Advances in Clinical Virology ( A. P. Waterson, ed.), pp. 93–115, Livingston, New York.Google Scholar
  17. 17.
    Szmuness, W., 1978, Hepatocellular carcinoma and the hepatitis B virus: Evidence for a causal association, Prog. Med. Virol. 24: 40–69.PubMedGoogle Scholar
  18. 18.
    Salahuddin, S. Z., Alblashi, D. V., Markham, P. D., Josephs, S. F., Sturzenegger, S., Kaplan, M., Halligan, G., Biberfield, P., Wong-Staal, F., Kramarsky, B., and Gallo, R. C., 1986, Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders, Science 234: 596–601.PubMedCrossRefGoogle Scholar
  19. 19.
    Ellermann, V., and Bang, O., 1908, Experimentelle Leukamie bei Huhitem, Zentralbi. Bakteriol. 46: 595.Google Scholar
  20. 20.
    Rous, P. A., 1911, Sarcoma of the fowl transmissible by an agent separable from the tumor cells, J. Exp. Med. 13: 397.PubMedCrossRefGoogle Scholar
  21. 21.
    Fujinami, A., and Inamoto, K., 1914, Uber Geschwulste bei japanischen Haushuhnem insbesondere uber einen Transplantablen Tumor, Zeitschr. Krebsforsch. 14: 94–119.CrossRefGoogle Scholar
  22. 22.
    Bittner, J. J., 1936, Some possible effects of nursing on the mammary gland tumor incidence of mice, Science 84: 162–163.PubMedCrossRefGoogle Scholar
  23. 23.
    Gross, L., 1951, “Spontaneous” leukemia developing in C3H mice following inoculation in infancy, with AK leukemic extracts, or AK embryos, Proc. Soc. Exp. Biol. Med. 76:27.Google Scholar
  24. 24.
    Graffi, A., Bielka, H., Fey, F., and Marchiani, P., 1955, Gehauftes Aufreten von Leukamien nach Injection von Sarkomfiltraten, Wien. Klin. Wochenschr. 105: 61.Google Scholar
  25. 25.
    Friend, C., 1957, Cell-free transmission in adult Swiss mice of a disease having the character of a leukemia, J. Exp. Med. 105: 307–318.PubMedCrossRefGoogle Scholar
  26. 26.
    Lieberman, M., and Kaplan, H. S., 1959, Leukemogenic activity of filtrates from radiation-induced lymphoid tumors of mice, Science 130: 387–388.PubMedCrossRefGoogle Scholar
  27. 27.
    Moloney, J. B., 1960, Biological studies on a lymphoid leukemia virus extracted from sarcoma S37. I. Origin and introductory investigations, J. Natl. Cancer Inst. 24: 933–951.PubMedGoogle Scholar
  28. 28.
    Rauscher, F. J., 1962, A virus-induced disease of mice characterized by erythrocytopoiesis and lymphoid leukemia, J. Natl. Cancer Inst. 29: 515–543.PubMedGoogle Scholar
  29. 29.
    Harvey, J. J., 1964, An unidentified virus which causes the rapid production of tumours in mice, Nature (Lond.) 204: 1104–1105.CrossRefGoogle Scholar
  30. 30.
    Moloney, J. B., 1966, A virus-induced rhabdomyosarcoma of mice, Natl. Cancer Inst. Monog. 22: 139–142.Google Scholar
  31. 31.
    Finkel, M. P., Biskis, B. O., and Jinkins, P. B., 1966, Virus induction of osteosarcomas in mice, Science 151: 698–701.PubMedCrossRefGoogle Scholar
  32. 32.
    Hehlmann, R., Schetters, H., and Erfle, V., 1984, RNA tumor viruses. in: Human Virology (R. B. Belshe, ed.), PSG, pp. 139–178, Littleton, Massachusetts.Google Scholar
  33. 33.
    Jarrett, W. F. H., Martin, W. B., Crighton, G. W., Dalton, R. G., and Stewart, M. F., 1964, Leukemia in the cat: Transmission experiments with leukemia (lymphosarcoma), Nature (Lond.) 202: 566–568.CrossRefGoogle Scholar
  34. 34.
    Kawakami, T. G., Theilen, G. H., Dungworth, D. L., Munn, R. J., and Beall, S. G., 1967, “C”-type viral particles in plasma of cats with feline leukemia, Science 158: 1049–1050.Google Scholar
  35. 35.
    Rickard, C. G., Post, J. E., Noronha, F., and Barr, L. M., 1969, A transmissable virus-induced lymphocytic leukemia of the cat, J. Natl. Cancer Inst. 42: 987–1014.PubMedGoogle Scholar
  36. 36.
    Snyder, S. P., and Theilen, G. H., 1969, Transmissible feline fibrosarcoma, Nature (Lond.) 221: 1074–1075.CrossRefGoogle Scholar
  37. 37.
    Chopra, H. S., and Mason, M. M., 1970, A new virus in a spontaneous mammary tumor of a Rhesus monkey, Cancer Res. 30: 2081–2086.PubMedGoogle Scholar
  38. 38.
    Verma, I. M., 1977, The reverse transcriptase, Biochim. Biophys. Acta 473: 1–38.PubMedGoogle Scholar
  39. 39.
    Alberts, B., Bray, D., Lewis, J., Raff, M., Roberts, K., and Watson, J. D., 1983, Molecular Biology of the Cell, Garland, New York.Google Scholar
  40. 40.
    Wolfe, L. G., Deinhardt, F., Theilen, G. H., Rabin, H., Kawakami, T., and Bustad, L. K., 1971, Induction of tumors in marmoset monkeys by simian sarcoma virus, type 1 (lagothrix): A preliminary report, J. Natl. Cancer Inst. 47: 1115–1120.PubMedGoogle Scholar
  41. 41.
    Duesberg, P. H., and Vogt, P. K., 1973, Differences between the ribonucleic acids of transforming and nontransforming avian tumor viruses, Proc. Natl. Acad. Sci. USA 67: 1673–1680.CrossRefGoogle Scholar
  42. 42.
    Stehelin, D., Varmus, H. E., Bishop, J. M., and Vogt, P. K., 1976, DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal DNA, Nature (Lond.) 260: 170–173.CrossRefGoogle Scholar
  43. 43.
    Bishop, J. M., 1980, The molecular biology of RNA tumor viruses: A physician’s guide, N. Engl. J. Med. 303: 675–682.PubMedCrossRefGoogle Scholar
  44. 44.
    Poiesz, B. J., Ruscetti, F. W., Gazdar, A. F., Bunn, P. A., Minna, J. D., and Gallo, R. C., 1980, Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma, Proc. Natl. Acad. Sci. USA 77: 7415–7419.PubMedCrossRefGoogle Scholar
  45. 45.
    Poiesz, B. J., Ruscetti, F. W., Reitz, M. S., Kalyanaraman, V. S., and Gallo, R. C., 1981, Isolation of a new type C retrovirus (HTLV) in primary uncultured cells of a patient with Sezary T-cell leukemia, Nature (Lond.) 294: 268–271.CrossRefGoogle Scholar
  46. 46.
    Jawetz, E., Melnick, J. L., and Adelberg, E. A., 1987, Tumor viruses and oncogenes, in: Review of Medical Microbiology ( E. Jawetz, J. L. Melnick, and E. A. Adelberg, eds.), pp. 519–532, Appleton & Lange, E. Norwalk, Connecticut.Google Scholar
  47. 47.
    Monier, R., and Salzman, N. P., 1983, History and overview of oncogenic DNA viruses, in: Viruses Associated with Human Cancer ( L. A. Phillips, ed.), pp. 3–35, Marcel, New York.Google Scholar
  48. 48.
    Lowy, D. R., 1985, Transformation and oncogenesis: Retroviruses, in: Virology ( B. N. Fields, ed.), pp. 235–263, Raven, New York.Google Scholar
  49. 49.
    Coffin, J. M., 1982, Structure of the retroviral genomes, in: Molecular Biology of Tumor Viruses: RNA Tumor Viruses ( R. A. Weiss, N. Teich, H. E. Varmus, and J. M. Coffin, eds.) pp. 261–368, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.Google Scholar
  50. 50.
    Gordon, H., 1985, Oncogenes, Mayo Clin. Proc. 60: 697–713.PubMedGoogle Scholar
  51. 51.
    Graf, T., and Stehelin, D., 1982, Avian leukemia viruses. Oncogenes and genome structure, Biochim. Biophys. Acta 651: 245–271.PubMedGoogle Scholar
  52. 52.
    Shilo, B. Z., 1984, Evolution of cellular oncogenes, Adv. Virol. Oncol. 4: 29–44.Google Scholar
  53. 53.
    Shilo, B. Z., and Weinberg, R. A., 1981, DNA sequences homologous to vertebrate oncogenes are conserved in Drosophila melanogaster, Proc. Natl. Acad. Sci. USA 78: 6789–6792.PubMedCrossRefGoogle Scholar
  54. 54.
    Dejean, A., Bougueleret, L., Grzeschik, K. H., and Tiollais, P., 1986, Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma, Nature (Lond.) 322: 70–72.CrossRefGoogle Scholar
  55. 55.
    Hino, O., Shows, T. B., and Rogler, C. E., 1986, Hepatitis B virus integration site in hepatocellular carcinoma at chromosome 17;18 translocation, Proc. Natl. Acad. Sci. USA 83: 8338–8342.PubMedCrossRefGoogle Scholar
  56. 56.
    Macara, I. G., 1985, Oncogenes, ions and phospholipids, Am. J. Physiol. 248 (pt. 1): 3–11.Google Scholar
  57. 57.
    Vogt, M., and Dulbecco, R., 1960, Virus-cell interaction with a tumor-producing virus, Proc. Natl. Acad. Sci. USA 46: 365–370.PubMedCrossRefGoogle Scholar
  58. 58.
    Lancaster, W. D., and Olson, C., 1982, Animal papillomaviruses, Microbiol. Rev. 46: 191–207.PubMedGoogle Scholar
  59. 59.
    Rawls, W. E., Clarke, A., Smith, K. O., Docherty, J. J., Gilman, S. C., and Graham, S., 1980, Specific antibodies to herpes simplex virus type 2 among women with cervical cancer, in: Viruses in Naturally Occurring Cancers, Vol. 7 ( M. Essex, G. Todaro, and H. zur Hausen, eds.), pp. 117–133, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.Google Scholar
  60. 60.
    Green, M., Brackmann, K. H., Sanders, P. R., Loewenstein, P. M., Freel, J. H., Eisinger, M., and Switlyk, S. A., 1982, Isolation of a human papillomavirus from a patient with epidermodysplasia verruciformis: Presence of related viral DNA genomes in human urogenital tumors, Proc. Natl. Acad. Sci. USA 79: 4437–4441.PubMedCrossRefGoogle Scholar
  61. 61.
    Orth, G., Favre, M., Breitburd, F., Croissant, O., Jablonska, S., Obalek, S., Jarzabet-Chorzelska, M., and Rzesa, G., 1980, Epidermodysplasia verruciformis: A model for the role of papilloma viruses in human cancer, in: Viruses in Naturally Occurring Cancers, Vol. 7 ( M. Essex, G. Todaro, and H. zur Hausen, eds.), pp. 259–282, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.Google Scholar
  62. 62.
    Galloway, D. A., and McDougall, J. K., 1983, The oncogenic potential of herpes simplex viruses: Evidence of a “hit-and-run” mechanism, Nature (Land.) 302: 21–24.CrossRefGoogle Scholar
  63. 63.
    zur Hausen, H., 1982, Human genital cancer: Synergism between two virus infections or synergism between a virus infection and initiating events?, Lancet 2: 1370–1372.PubMedCrossRefGoogle Scholar
  64. 64.
    London, W. T., 1983, Hepatitis B virus and primary hepatocellular carcinoma, in: Advances in Viral Oncology, Vol. 3 ( G. Klein, ed.), pp. 325–341, Raven, New York.Google Scholar
  65. 65.
    Summers, J., and Mason, W. S., 1982, Properties of the hepatitis B-like viruses related to their taxonomic classification, Hepatology 2: 61S - 66S.Google Scholar
  66. 66.
    Coffin, J. M., 1982, Endogenous proviruses, in: Molecular Biology of Tumor Viruses: RNA Tumor Viruses ( R. A. Weiss, N. Teich, H. E. Varmus, and J. M. Coffin, eds.), pp. 1109–1204, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.Google Scholar
  67. 67.
    Crittenden, L. B., 1981, Exogenous and endogenous leukosis virus genes, Avian Pathol. 10: 101–112.PubMedCrossRefGoogle Scholar
  68. 68.
    Jaenisch, R., 1983, Endogenous retroviruses, Cell 32: 5–6.PubMedCrossRefGoogle Scholar
  69. 69.
    Pincus, T., 1980, The endogenous murine type C virus, in: Molecular Biology of RNA Tumor Viruses ( J. Stephenson, ed.), pp. 77–130, Academic, New York.Google Scholar
  70. 70.
    O’Rear, J. J., and Temin, H. M., 1982, Spontaneous changes in nucleotide sequences in provirus of spleen necrosis virus, an avian retrovirus, Proc. Natl. Acad. Sci. USA 79: 1230–1234.PubMedCrossRefGoogle Scholar
  71. 71.
    Todaro, G. J., 1980, Interspecies transmission mammalian retroviruses, in: Molecular Biology of RNA Tumor Viruses ( J. R. Stephenson, ed.), pp. 47–76, Academic, New York.Google Scholar
  72. 72.
    Cohen, J. C., and Varmus, H. E., 1979, Endogenous mammary tumour virus DNA varies among wild mice and segregates during inbreeding, Nature (Lond.) 278: 418–423.CrossRefGoogle Scholar
  73. 73.
    Robinson, H. L., Astrin, S. M., Senior, A. M., and Salzar, F H., 1981, Host susceptibility to endogenous viruses: Defective, glycoprotein-expressing proviruses interfere with infections, J. Virol. 40: 745–751.PubMedGoogle Scholar
  74. 74.
    Robinson, H. L., Blais, B. M., Tsichlis, P. N., and Coffin, J. M., 1982, At least two regions of the viral genome determine the oncogenic potential of avian leukosis viruses, Proc. Natl. Acad. Sci. USA 79: 1225–1229.PubMedCrossRefGoogle Scholar
  75. 75.
    Cullen, B. R., Skalka, A. M., and Ju, G., 1983, Endogenous avian retroviruses contain deficient promoter and leader sequences, Proc. Natl. Acad. Sci. USA 80: 2946–2950.PubMedCrossRefGoogle Scholar
  76. 76.
    Ralston, R., and Bishop, J. M., 1983, The protein products of the myc and myb oncogenes and adenovirus Ela are structurally related, Nature (Lond.) 306: 803–806.CrossRefGoogle Scholar
  77. 77.
    Gelmann, H. P., Clanton, D. J., Jariwalla, R. J., and Rosenthal, L. J., 1983, Characterization and location of myc homologous sequences in human cytomegalovirus DNA, Proc. Natl. Acad. Sci. USA 80: 5107–5111.PubMedCrossRefGoogle Scholar
  78. 78.
    Spector, D. H., and Vacquier, J. P., 1983, Human cytomegalovirus (strain AD169) contains sequences related to the avian retrovirus oncogene v-myc, Proc. Natl. Acad. Sci. USA 80: 3889–3893.PubMedCrossRefGoogle Scholar
  79. 79.
    Robinson, W. S., Miller, R. H., and Marion, P. L., 1987, Hepadnaviruses and retroviruses share genome homology and features of replication, Hepatology 7: 64S - 73S.PubMedCrossRefGoogle Scholar
  80. 80.
    Miller, R. H., and Robinson, W. S., 1986, Common evolutionary origin of hepatitis B virus and retroviruses, Proc. Natl. Acad. Sci. USA 83: 2531–2535.PubMedCrossRefGoogle Scholar
  81. 81.
    Bishop, J. M., 1983, Cellular oncogenes and retroviruses, Annu. Rev. Biochem. 52: 301–354.PubMedCrossRefGoogle Scholar
  82. 82.
    Wold, W. S. M., Mackey, J. K., Brackmann, K. H., Takemori, N., Rigden, P., and Green, M. 1978. Analysis of human tumors and human malignant cell lines for BK virus specific DNA sequences, Proc. Natl. Acad. Sci. USA 75: 454–458.PubMedCrossRefGoogle Scholar
  83. 83.
    Jarrett, W. F. H., McNeil, P. E. Grimshaw, W. T. R., Selman, I. E., and McIntyre, W. I. M., 1978, High incidence area of cattle cancer with a possible interaction between an environmental carcinogen and a papilloma virus, Nature (Lond.) 274: 215–217.Google Scholar
  84. 84.
    Kidd, J. G., and Rous, P., 1940, Cancers deriving from the virus papillomas of wild rabbits under natural conditions, J. Exp. Med. 71: 469–494.PubMedCrossRefGoogle Scholar
  85. 85.
    Mueller, H., and Grissmann, L., 1978, Mastomys natalensis papilloma virus (MnPV), the causative agent of epithelial proliferations: Characterization of the virus particle, J. Gen. Virol. 41: 315–323.Google Scholar
  86. 86.
    Ito, Y., 1960, A tumor-producing factor extracted by phenol from papillomatous tissue (Shope) of cottontail rabbits, Virology 12: 596–601.PubMedCrossRefGoogle Scholar
  87. 87.
    Coggin, J. R., and zur Hausen, H., 1979, Workshop on papillomaviruses and cancer, Cancer Res. 39: 545–546.Google Scholar
  88. 88.
    Zachow, K. R., Ostrow, R. S., Bender, M., Watts, S., Okagaki, T., Pass, F., and Faras, A. J., 1982, Detection of human papillomavirus DNA in anogenital neoplasias, Nature (Lond.) 300: 771–773.CrossRefGoogle Scholar
  89. 89.
    Durst, M., Grissmann, L., Ikenberg, H., and zur Hausen, H., 1983, A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions, Proc. Natl. Acad. Sci. USA 80: 3812–3815.PubMedCrossRefGoogle Scholar
  90. 90.
    Grissman, L., Wolnik, L., Ikenberg, H., Koldovsky, U., Schurch, H. G., and zur Hausen, H., 1983, Human papillomavirus types 6 and 11 DNA sequences in genital and laryngeal papillomas and in some cervical cancer, Proc. Natl. Acad. Sci. USA 80: 560–563.CrossRefGoogle Scholar
  91. 91.
    Kreider, J. W., Howett, M. K., Wolfe, S. A., Bartlett, G. L., Zaino, R. J., Sedlacek, T. V., and Mortel, R., 1985, Morphological transformation in vivo of human uterine cervix with papillomavirus from condylomata acuminata, Nature (Lond.) 317: 639–641.CrossRefGoogle Scholar
  92. 92.
    Syrjanen, K. J., 1980, Epithelial lesions suggestive of a condylomatous origin found closely associated with invasive bronchial squamous cell carcinomas, Respiration 40: 150–160.PubMedCrossRefGoogle Scholar
  93. 93.
    Kurman, R. J., Shah, K. H., Lancaster, W. D., and Jenson, A. B., 1981, Immunoperoxidase localization of papillomavirus antigens in cervical dysplasia and vulvar condylomas, Am. J. Obstet. Gynecol. 140: 931–935.PubMedGoogle Scholar
  94. 94.
    Woodruff, J. D., Braun, L., Cavalieri, R., Gupta, P., Pass, F., and Shah, K., 1981, Immunological identification of papillomavirus antigen in paraffin-processed condyloma tissues from the female genital tract, Obstet. Gynecol. 56: 727–732.Google Scholar
  95. 95.
    Syrjanen, K. J., 1984, Current concepts of human papillomavirus infections in the genital tract and their relationship to intraepithelial neoplasia and squamous cell carcinoma, Obstet. Gynecol. 39: 252–265.Google Scholar
  96. 96.
    Syrjanen, K. J., 1982, Histological changes identical to those of condylomatous lesions found in esophageal squamous cell carcinomas, Arch. Geschwulstforsch. 52: S283–5292.Google Scholar
  97. 97.
    Syrjanen, K. J., and Syrjanen, S. M., 1981, Histological evidence for the presence of condylomatous epithelial lesions in association with laryngeal squamous cell carcinoma, ORLI Otorhinolaryngol. Relat. Spec. 43: 181–194.CrossRefGoogle Scholar
  98. 98.
    Grissmann, L., Diehl, V., Schultz-Coulon, H.-J., and zur Hausen, H., 1982, Molecular cloning and characterization of human papilloma virus DNA derived from a laryngeal papilloma, J. Virol. 44: 393–400.Google Scholar
  99. 99.
    Pfister, H., Hettich, I., Runne, U., Grissmann, L., and Chilf, G. N., 1983, Characterization of human papillomavirus type 13 from focal epithelial hyperplasia neck lesions, J. Virol. 47: 363–366.PubMedGoogle Scholar
  100. 100.
    Green, M., 1971, Search for adenovirus messenger RNA in cancers of man, in: Oncology ( L. Clark, R. W. Gumley, J. E. McCay, and M. M. Copeland, eds.), pp. 156–165, Year Book Medical Publishers, Chicago.Google Scholar
  101. 101.
    Jonsson, N., and Ankerst, J., 1977, Studies on adenovirus type 9-induced mammary fibroadenomas in rats and their malignant transformation, Cancer 39: 2513–2519.PubMedCrossRefGoogle Scholar
  102. 102.
    Bernards, R., Schrier, P. I., Houweling, A., Box, J. L., and van der Eb, A. J., 1983, Tumorigenicity of cells transformed by adenovirus type 12 by evasion of T-cell immunity, Nature (Lond.) 305: 776–779.CrossRefGoogle Scholar
  103. 103.
    Schrier, P. I., Bernards, R., Vaessen, R. T. M. J., Houweling, A., and van der Eb, A. J., 1983, Expression of class I major histocompatibility antigens switched off by highly oncogenic adenovirus 12 in transformed rat cells, Nature (Lond.) 305: 771–775.CrossRefGoogle Scholar
  104. 104.
    Roizman, B., 1982, The family herpesviridae: General description, taxonomy, and classification, in: The Viruses. The Herpesviruses, Vol. 1 ( B. Roizman, ed.), pp. 1–23, Plenum, New York.Google Scholar
  105. 105.
    Duff, R., and Rapp, F., 1973, Oncogenic transformation of hamster embryo cells after exposure to inactivated herpes simplex virus type 1, J. Virol. 12: 209–217.PubMedGoogle Scholar
  106. 106.
    Duff, R., and Rapp, F., 1971, Oncogenic transformation of hamster cells after exposure to herpes simplex virus type 2, Nature (Lond.) 233: 48–50.CrossRefGoogle Scholar
  107. 107.
    Maitland, N. J., Kinross, J. H., Busuttil, A., Ludgate, S. M., Smart, G. E., and Jones, K. W., 1981, The detection of DNA tumour virus-specific RNA sequences in abnormal human cervical biopsies by in situ hybridization, J. Gen. Virol. 55: 123–127.PubMedCrossRefGoogle Scholar
  108. 108.
    McDougall, J. K., Crum, C. P., Fenoglio, C. M., Goldstein, L. C., and Galloway, D. A., 1982, Herpesvirus-specific RNA and protein in carcinoma of the uterine cervix, Proc. Natl. Acad. Sci. USA 79: 3853–3857.PubMedCrossRefGoogle Scholar
  109. 109.
    Vonka, V., Kanka, J., Jelinek, J., Subrt, I., Suchanek, A., Havrankova, A., Vachal, M., Hirsch, I., Domorazkova, E., Zavadova, H., Richterova, V., Naprstkova, J., Dvorakova, V., and Svoboda, B., 1984, Prospective study on the relationship between cervical neoplasia and herpes simplex type-2 virus I. Epidemiological characteristics, Int. J. Cancer 33: 49–60.PubMedCrossRefGoogle Scholar
  110. 110.
    Galloway, D. A., Nelson, J. A., and McDougall, J. K., 1984, Small fragments of herpesvirus DNA with transforming activity contain insertion sequence-like structures, Proc. Natl. Acad. Sci. USA 81: 4736–4740.PubMedCrossRefGoogle Scholar
  111. 111.
    Nelson, J. A., Fleckenstein, B., Galloway, D. A., and McDougall, J. K., 1982, Transformation of NIH 3T3 cells with cloned fragments of human cytomegalovirus strain AD169, J. Virol. 43: 83–91.PubMedGoogle Scholar
  112. 112.
    Huang, E.-S., Boldogh, I., and Mar, E.-C., 1983, Human cytomegaloviruses: Evidence for possible association with human cancer, in: Viruses Associated with Human Cancer (L. A. Phillips, ed.), pp. 161194, Dekker, New York.Google Scholar
  113. 113.
    Zagury, D., Bemard, J., Leonard, R., Cheynier, R., Feldman, M., Sarin, P. S., and Gallo, R. C., 1986, Long-term cultures of HTLV-III-infected T cells: A model of cytopathology of T-cell depletion in AIDS, Science 231: 850–853.PubMedCrossRefGoogle Scholar
  114. 114.
    Mosca, J. D., Bednarik, D. P., Raj, N. B. K., Rosen, C. A., Sodroski, J. G., Haseltine, W. A., and Pitha, P. M., 1987, HSV-1 can reactivate transcription of latent HIV, Nature (Lond.) 325: 67–70.CrossRefGoogle Scholar
  115. 115.
    Yamamoto, N., 1984, Interaction of viruses with tumor promotors, Rev. Physiol. Biochem. Pharmacol. 101: 111–159.PubMedCrossRefGoogle Scholar
  116. 116.
    Epstein, M. A., 1986, Vaccination against Epstein-Barr virus: Current progress and future strategies, Lancet 2: 1425–1427.CrossRefGoogle Scholar
  117. 117.
    Josephs, S. F., Salahuddin, S. Z., Ablashi, D. V., Schachter, F., Wong-Staal, F., and Gallo, R. C., 1986, Genomic analysis of the human B-lymphotropic virus (HBLV), Science 234: 601–603.PubMedCrossRefGoogle Scholar
  118. 118.
    Swenson, P. D., Escobar, M. R., and Silverman, J. F., 1980, Hepatitis B virus and core antigens in the liver of primary hepatocellular carcinoma cases in Virginia, Acta Biol. Acad. Sci. Hung. 31: 321–328.PubMedGoogle Scholar
  119. 119.
    Lieberman, H. M., and Shafritz, D., 1986, Persistent hepatitis B virus infection and hepatocellular carcinoma, in: Progress in Liver Diseases VIII ( H. Popper and F. Schaffner, eds.), pp. 395–415, Grune & Stratton, New York.Google Scholar
  120. 120.
    Wu, T. C., Tong, M. J., Hwang, B., Lee, S. D., and Hu, M. M., 1987, Primary hepatocellular carcinoma and hepatitis B infection during childhood, Hepatology 7: 46–48.PubMedCrossRefGoogle Scholar
  121. 121.
    Brechot, C., Pourcel, C., Louise, A., Rain, B., and Tiollais, P., 1980, Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma, Nature (Lord.) 286: 533–535.CrossRefGoogle Scholar
  122. 122.
    Shafritz, D. A., and Kew, M. C., 1981, Identification of integrated hepatitis B virus DNA sequences in human hepatocellular carcinomas, Hepatology 1: 1–8.PubMedCrossRefGoogle Scholar
  123. 123.
    Hayward, W. S., Neel, B. G., and Astrin, S. M., 1981, Activation of a cellular one gene by promoter insertion in ALV-induced lymphoid leukosis, Nature (Lond.) 290: 475–480.CrossRefGoogle Scholar
  124. 124.
    Neel, B. G., Hayward, W. S., Robinson, H. L., Fang, J., and Astrin, S. M., 1981, Avian leukosis virus-induced tumors have common proviral integration sites and synthesize discrete new RNA’s: Oncogenesis by promoter insertion, Cell 23: 323–334.PubMedCrossRefGoogle Scholar
  125. 125.
    Payne, G. S., Courtneidge, S. A., Crittenden, L. B., Fadly, A. M., Bishop, J. M., and Varmus, H. E., 1981, Analysis of avian leukosis virus DNA and RNA in bursal tumors: Viral gene expression is not required for maintenance of the tumor state, Cell 23: 311–322.PubMedCrossRefGoogle Scholar
  126. 126.
    Koshy, R., Koch, S., von Loringhoven, A. F., Kahmann, R., Murray, R., and Hofschneider, P. H., 1983, Integration of hepatitis B virus DNA: Evidence for integration in the single-stranded gap, Cell 34: 215–223.PubMedCrossRefGoogle Scholar
  127. 127.
    Gallo, R. C., Wong-Staal, F., and Ruscetti, F., 1982, Viruses and adult leukemia—lymphoma of man and relevant animal models, in: Adult Leukemias ( C. D. Bloomfield, ed.), pp. 141–215, Martinus Nijhoff, The Hague.Google Scholar
  128. 128.
    Hehlmann, R., Schetters, H., and Erfle, V., 1984, Current understanding of viral etiology in leukemia, in: Leukemia, Recent Results in Cancer Research ( E. Thiel and S. Thierfelder, eds.), pp. 1–28, Springer-Verlag, Berlin.Google Scholar
  129. 129.
    Chandra, P., and Steel, L. K., 1977, Purification, biochemical characterization and serological analysis of cellular deoxyribonucleic acid polymerases and a reverse transcriptase from spleen of a patient with myelofibrotic syndrome, Biochem. J. 167: 315–523.Google Scholar
  130. 130.
    Hehlmann, R., Schetters, H., Erfle, V., and Leib-Mosch, C., 1983, Detection and biochemical characterization of antigens in human leukemic sera that crossreact with primate C-type viral p30 proteins, Cancer Res. 43: 392–399.PubMedGoogle Scholar
  131. 131.
    Herbrink, P., Moen, J. E. T., Brouwer, J., and Warnaar, S. O., 1980, Detection of antibodies cross-reactive with type-C RNA tumor viral p30 protein in human sera and exudate fluids, Cancer Res. 40: 166–173.PubMedGoogle Scholar
  132. 132.
    Jacquemin, P. C., Saxinger, C., and Gallo, R. C., 1978, Surface antibodies of human myelogenous leukemia leukocytes reactive with specific type-C viral reverse transcriptases, Nature (Land.) 276: 230–236.CrossRefGoogle Scholar
  133. 133.
    Gallagher, R. E., and Gallo, R. C., 1975, Type-C RNA tumor virus isolated from cultured human acute myelogenous leukemia cells, Science 187: 350–353.PubMedCrossRefGoogle Scholar
  134. 134.
    Nooter, K., Aarson, A. M., Bentvelze, P., deGroot, F. G., and Van Pelt, F. G., 1975, Isolation of infectious C-type oncomavirus from human leukemic bone marrow cells, Nature (Lond.) 256: 595–597.CrossRefGoogle Scholar
  135. 135.
    Panem, S., Prochownik, E. V., Reale, F. R., and Kirsten, W. H., 1975, Isolation of type C virions from a normal human fibroblast strain, Science 189: 297–299.PubMedCrossRefGoogle Scholar
  136. 136.
    Kaplan, H. S., Goodenow, R. S., Epstein, A. L., Gartner, S., Decleve, A., and Rosenthal, P. N., 1977, Isolation of a type C RNA virus from an established human histiocytic lymphoma cell line, Proc. Natl. Acad. Sci. USA 74: 2564–2568.PubMedCrossRefGoogle Scholar
  137. 137.
    Bonner, T. I., Connell, C. O., and Cohen, M., 1982, Cloned endogenous retroviral sequences from human DNA, Proc. Natl. Acad. Sci. USA 79: 4709–4713.PubMedCrossRefGoogle Scholar
  138. 138.
    Martin, M. A., Bryan, T., Rasheed, S., and Kahn, A. S., 1981, Identification and cloning of endogenous retroviral sequences present in human DNA, Proc. Natl. Acad. Sci. USA 78: 4892–4896.PubMedCrossRefGoogle Scholar
  139. 139.
    O’Brien, S. J., Bonner, T. I., Cohen, M., O’Connell, C., and Nash, W. G., 1983, Mapping of an endogenous retroviral sequence to human chromosome 18, Nature (Lond.) 303: 74–77.CrossRefGoogle Scholar
  140. 140.
    Repaske, R., O’Neill, R. R., Steele, P. E., and Martin, M. A., 1983, Characterization and partial nucleotide sequence of endogenous type C retrovirus segments in human chromosomal DNA, Proc. Natl. Acad. Sci. USA 80: 678–682.PubMedCrossRefGoogle Scholar
  141. 141.
    Poiesz, B. J., Ruscetti, F. W., Mier, J. W., Woods, A. M., and Gallo, R. C., 1980, T-cell lines established from human T-lymphocytic neoplasias by direct response to T-cell growth factor, Proc. Natl. Acad. Sci. USA 77: 6815–6819.PubMedCrossRefGoogle Scholar
  142. 142.
    Hehlmann, R., 1976, RNA tumor viruses and human cancer, in: Current Topics in Microbiology and Immunology, Vol. 73, pp. 141–215, Springer-Verlag, Berlin.Google Scholar
  143. 143.
    Pimentel, E., 1979, Human oncovirology, Biochim. Biophys. Acta 560: 169–216.PubMedGoogle Scholar
  144. 144.
    Ohno, T., and Spiegelman, S., 1977, Antigenic relatedness of the DNA polymerase of human breast cancer particles to the enzyme of the Mason—Pfizer monkey virus. Proc. Natl. Acad. Sci. USA 74: 2144–2148.PubMedCrossRefGoogle Scholar
  145. 145.
    Dion, A. S., Farwell, D. C., Pomenti, A. A., and Girardi, A. J., 1980, A human protein related to the major envelope protein of murine mammary tumor virus: Identification and characterization, Proc. Natl. Acad. Sci. USA 77: 1301–1305.PubMedCrossRefGoogle Scholar
  146. 146.
    Welte, K., Ebener, U., and Chandra, P., 1979, Serological characterization of a purified reverse transcriptase from osteosarcoma of a child, Cancer Lett. 7: 189–195.PubMedCrossRefGoogle Scholar
  147. 147.
    Zurcher, C., Brinkhof, J., Bentvelzen, P., and deMan, J. C. H., 1975, C-type virus antigens detected by immunofluorescence in human bone tumor cultures, Nature (Lond.) 254: 457–459.Google Scholar
  148. 148.
    Chandra, P., Balikcioglu, S., and Mildner, B., 1978, Biochemical and immunological characterization of a reverse transcriptase from human melanoma tissue, Cancer Lett. 5: 299–310.PubMedCrossRefGoogle Scholar
  149. 149.
    Balda, B. R., Hehlmann, R., Cho, J. R., and Spiegelman, S., 1975, Oncomavirus-like particles in human skin cancers, Proc. Natl. Acad. Sci. USA 72: 3697–3700.PubMedCrossRefGoogle Scholar
  150. 150.
    Parsons, P. G., Klucis, E., Gross, P. D., Pope, J. H., Little, J. H., and Davis, N. C., 1976, Oncornavirus-like particles in malignant melanoma and control biopsies, Int. J. Cancer 18: 757–763.PubMedCrossRefGoogle Scholar
  151. 151.
    Kalter, S. S., Helmke, R., Heberling, R. L., Panigel, M., Fowler, A.K., Strickland, J. E., and Hellman, A., 1973, C-type particles in normal human placentas, J. Natl. Cancer Inst. 50: 1081–1084.PubMedGoogle Scholar
  152. 152.
    Dirksen, E. R., and Levy, J. A., 1977, Virus-like particles in placentas from normal individuals and patients with systemic lupus erythematosus, J. Natl. Cancer Inst. 59: 1187–1192.PubMedGoogle Scholar
  153. 153.
    Sawyer, M. H., Nachlas, Jr., N. E., and Panem, S., 1978, C-type viral antigen expression in human placenta, Nature (Lord.) 275: 62–64.CrossRefGoogle Scholar
  154. 154.
    Thiry, L., Sprecher-Goldberger, S., Bossens, M., and Neurax, F., 1978, Cell-mediated immune response to simian oncornavirus antigens in pregnant women, J. Natl. Cancer Inst. 60: 527–532.PubMedGoogle Scholar
  155. 155.
    Callahan, R., Drohan, W., Tronick, S., and Schlom, J., 1982, Detection and cloning of human DNA sequences related to the mouse mammary tumor virus genome, Proc. Natl. Acad. Sci. USA 79: 5503–5507.PubMedCrossRefGoogle Scholar
  156. 156.
    Sell, S., 1987, Immunology, Immunopathology and Immunity, Elsevier, New York.Google Scholar
  157. 157.
    Stites, D. P., Stobo, J. D., and Wells, J. V., 1987, Tumor immunology. in: Basic and Clinical Immunology ( D. P. Stites, J. D. Stobo, and J. V. Wells, eds.), pp. 186 — I96, Appleton & Lange, E. Norwalk, Connecticut.Google Scholar
  158. 158.
    Herberman, R. B., and Bellanti, J. A., 1985, Immune defense mechanisms in tumor immunity, in: Immunology, Vol. III ( J. A. Bellanti, ed.), pp. 330–345, W. B. Saunders, Philadelphia.Google Scholar
  159. 159.
    Church, J. A., and Schlegel, R. J., 1985, Immune deficiency disorders, in: Immunology, Vol. III ( J. A. Bellanti, ed.), pp. 471–507. W. B. Saunders, Philadelphia.Google Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Mario R. Escobar
    • 1
  1. 1.Department of Pathology, Medical College of VirginiaVirginia Commonwealth UniversityRichmondUSA

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