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Angiogenesis

Factors and Mechanisms

  • Chapter
Book cover The Pathobiology of Neoplasia

Abstract

Blood vessel proliferation is essential for the normal growth and development of tissue. In the adult, angiogenesis occurs infrequently. Exceptions are found in the female reproductive system, where angiogenesis occurs in the follicle during its development, in the corpus luteum during ovulation, and in the placenta during pregnancy. These periods of angiogenesis are relatively brief and tightly regulated. Normal angiogenesis also occurs as part of the body’s repair processes, such as in the healing of wounds and fractures. On the other hand, uncontrolled angiogenesis contributes to a wide variety of serious diseases. As examples, the growth of solid tumors is dependent on vascularization, and in diabetic retinopathy vascularization of the retina often leads to blindness.

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Authors and Affiliations

  1. Laboratory of Surgical Research and Department of Pathology, Children’s Hospital and Harvard Medical School, Boston, Massachusetts, 02115, USA

    Patricia A. D’Amore

  2. Laboratory of Surgical Research and Department of Biological Chemistry, Children’s Hospital and Harvard Medical School, Boston, Massachusetts, 02115, USA

    Michael Klagsbrun

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  1. Patricia A. D’Amore
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  2. Michael Klagsbrun
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Editors and Affiliations

  1. Department of Pathology, Medical of College of Virginia, Virginia Commonwealth University, 23298, Richmond, Virginia, USA

    Alphonse E. Sirica

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© 1989 Plenum Press, New York

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D’Amore, P.A., Klagsbrun, M. (1989). Angiogenesis. In: Sirica, A.E. (eds) The Pathobiology of Neoplasia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5523-6_27

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  • DOI: https://doi.org/10.1007/978-1-4684-5523-6_27

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