Ectopic Hormone Production and Neoplasia

  • David P. Rose


When the term “ectopic hormone production” was coined by Liddle and colleagues,1 the intent was to describe a situation in which hormones are secreted by tumors of tissues not normally responsible for their production. The classic clinical presentation was of Cushing syndrome occurring in patients with tumors which were not associated with the pituitary or adrenal glands. If effective therapy were possible, extirpation of the cancer resulted in regression of the endocrine disorder. Furthermore, cases are seen in which an endocrine tumor secretes both the hormone appropriate to its tissue of origin (eutopic production), plus others not normally produced by that endocrine gland (ectopic production). While this original definition is of value clinically, it is now recognized that the range of normal cells which secrete hormones extends far beyond those associated with the classical endocrine system.


Small Cell Carcinoma Cushing Syndrome Bronchial Carcinoid Ectopic ACTH Syndrome Humoral Hypercalcemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • David P. Rose
    • 1
  1. 1.Division of Nutrition and EndocrinologyAmerican Health FoundationValhallaUSA

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