Classification of Neoplasms
It is generally agreed by both experimental and clinical pathologists that it is much easier to describe the features that characterize neoplasia* than to try to devise a brief definition that would adequately encompass the total range and complexity of this condition. Nevertheless, two eminent pathologists of this century, Rupert A. Willis and James Ewing, separately provided concise definitions that together come very close to conveying the essence of the neoplastic state. In this regard, Willis1 stated that a neoplasm “is an abnormal mass of tissue, the growth of which exceeds and is uncoordinated with that of the normal tissues, and persists in the same excessive manner after cessation of the stimuli which evoked the change,” while Ewing’s definition, with minor modification,2 declares that “a neoplasm is a relatively autonomous growth of tissue.” What is implicit here is that (1) the neoplastic change is hereditable, being passed on to succeeding generations of cells; and (2) neoplastic cell proliferation is mostly, but not totally, free of the controls that act to regulate and limit the growth of normal cells and tissues.
KeywordsMalignant Neoplasm Basal Cell Carcinoma Transitional Cell Carcinoma Malignant Mesothelioma Fibrous Connective Tissue
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