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Activation of Oncogenes by Chemical Carcinogens

  • Marshall W. Anderson
  • Steven H. Reynolds

Abstract

Increasing evidence suggests that a small set of cellular genes appear to be targets for genetic alterations that contribute to the neoplastic transformation of cells. These genes, termed protooncogenes, appear to play a crucial role in normal cellular growth or differentiation since they are highly conserved in nature, being detected in species as divergent as yeast, Drosophila, and humans. Recent identification of a number of these genes as encoding for putative growth factors (sis,hst, int-2), growth factor receptors (neu, erb B, fms), proteins involved in the regulation of transmembrane signal transduction (ras), nuclear regulatory proteins (myc, myb, fos, jun), tyrosine kinases (src) and serine/threonine kinases (raf, mos) has served to substantiate this idea.

Keywords

Acute Myeloid Leukemia Cellular Oncogene Rodent Tumor Skin Papilloma Acute Myeloid Leuke 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Marshall W. Anderson
    • 1
  • Steven H. Reynolds
    • 1
  1. 1.Laboratory of Biochemical Risk AnalysisNational Institute of Environmental Health SciencesResearch Triangle ParkUSA

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