A unique disfigurement of acromegaly was seen in ancient paintings or statues, but the association of pituitary enlargement with this disease was first noted by Pierre Marie. Its association with growth hormone (GH) hypersecretion was suggested by Cushing and later confirmed by bioassay and radioimmunoassay (RIA). Since then, RIA has been extensively used in the diagnosis and evaluation of treatment of acromegaly.
KeywordsGrowth Hormone Pituitary Adenoma Vasoactive Intestinal Polypeptide Acromegalic Patient Luteinizing Hormone Release Hormone
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