The Role of Neurotransmitters in Growth Hormone Secretion

  • Eugenio E. Muller
  • Vittorio Locatelli
  • Silvano G. Cella
  • Sandro Loche
  • Ezio Ghigo
  • Daniela Cocchi
  • Franco Camanni
  • Carlo Pintor
Part of the Serono Symposia, USA book series (SERONOSYMP)


It is now a tenet of neuroendocrinology that the secretion of anterior pituitary (AP) hormones is regulated by the central nervous system (CNS) through a family of hypophysiotropic neuropeptides, the releasing and inhibiting hormones. In addition, the neuroregulation of a given AP hormone is influenced by a host of neurotransmitters and neuropeptides, which at hypothalamic and suprahypothalamic levels provide intermediate and obligatory links between hypophysiotropic and both exogenous and endogenous influences on hormone secretion (1,2), Figure 1 depicts schematically how neurotransmitter-neurohormonal interactions may occur at the hypothalamic level. The complexity of the system stems from the abundance of different neurotransmitter and neuropeptide neurons present in the mediobasal hypothalamus (MBH) and the various ways they may reciprocally interact. Another reason for complexity is the phenomenon of coexistence, which ultimately results from cotransmission, i.e., occurrence and then release of two transmitter substances present in the same nerve endings (3). Though cotransmission undoubtedly provides greater versatility and sophistication to the vocabulary of synaptic transmission (3), it compounds the understanding of the physiology and pathophysiology of neuroendocrine control.


Growth Hormone Growth Hormone Deficiency Growth Hormone Secretion Growth Hormone Response Growth Hormone Release 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Eugenio E. Muller
    • 1
    • 2
  • Vittorio Locatelli
    • 1
    • 2
  • Silvano G. Cella
    • 1
    • 2
  • Sandro Loche
    • 1
    • 2
  • Ezio Ghigo
    • 1
    • 2
  • Daniela Cocchi
    • 1
    • 2
  • Franco Camanni
    • 1
    • 2
  • Carlo Pintor
    • 1
    • 2
  1. 1.Departments of Pharmacology and BiomedicineUniversity of Milan and TurinItaly
  2. 2.Institute of PediatricsUniversity of CagliariItaly

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