Interaction of Growth Hormone and Nutritional Intake in Facilitating Nitrogen Conservation and Promoting Lipolysis
Growth hormone (GH) has multiple actions on target tissues that are coordinated to promote somatic growth. To provide adequate substrate for growth, GH has significant effects on carbohydrate, lipid and protein metabolism. While the effects on lipid and carbohydrate metabolism are believed to be direct or to be mediated through increased insulin secretion, the effects on protein synthesis are indirect, being mediated through the synthesis and secretion of somatomedin-C/insulin-like growth factor I (SmC/IGF-I), a potent stimulator of protein synthesis. The metabolic processes that coordinate the direct effects of GH with its indirect growth-promoting actions are incompletely understood.
KeywordsGrowth Hormone Caloric Restriction Human Growth Hormone Nitrogen Balance Ideal Body Weight
Unable to display preview. Download preview PDF.
- 8.Goldman JK, Bressler R. Growth hormone stimulation of fatty acid utilization by adipose tissue. Endocrinology 1968; 811: 306.Google Scholar
- 9.Mendel VJ. Influence of insulin to growth hormone ratio on body composition of mice. Am J Physiol 1979; 238: E231.Google Scholar
- 10.Freiberg SE, Merrimee TJ. Acute metabolic effects of human growth hormone. Diabetes 1979; 23: 499.Google Scholar
- 27.Smith AT, Clemmons DR, Ben Ezra V, McMurray R, UnderWood LE. Exercise modulates the response of somatomedin-C to dietary restriction. Metabolism (in press).Google Scholar