Interaction of Growth Hormone and Nutritional Intake in Facilitating Nitrogen Conservation and Promoting Lipolysis

  • David R. Clemmons
  • David K. Snyder
  • Louis E. Underwood
Part of the Serono Symposia, USA book series (SERONOSYMP)


Growth hormone (GH) has multiple actions on target tissues that are coordinated to promote somatic growth. To provide adequate substrate for growth, GH has significant effects on carbohydrate, lipid and protein metabolism. While the effects on lipid and carbohydrate metabolism are believed to be direct or to be mediated through increased insulin secretion, the effects on protein synthesis are indirect, being mediated through the synthesis and secretion of somatomedin-C/insulin-like growth factor I (SmC/IGF-I), a potent stimulator of protein synthesis. The metabolic processes that coordinate the direct effects of GH with its indirect growth-promoting actions are incompletely understood.


Growth Hormone Caloric Restriction Human Growth Hormone Nitrogen Balance Ideal Body Weight 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • David R. Clemmons
    • 1
  • David K. Snyder
    • 1
  • Louis E. Underwood
    • 1
  1. 1.Departments of Medicine and PediatricsUniversity of North Carolina School of MedicineChapel HillUSA

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