Growth Hormone Therapy in Turner’s Syndrome
The estimated incidence of Turner’s syndrome in live-born, phenotypic females varies between 1/2,000 and 1/10,000 (1). As such, it is a major cause of growth retardation, and, in many pediatric endocrine centers, is as common a diagnosis as classical growth hormone deficiency. Although significant variability in phenotypic expression exists, all major reviews of spontaneous growth in Turner’s syndrome demonstrate significant reduction in final adult heights (2–7). In Ranke’s 1983 review of growth in German girls with Turner’s syndrome (7), final adult height averaged 146.8 cm (-2.57 standard deviations), while previous reviews reported mean adult heights ranging from 140.2–146.3 cm.
KeywordsGrowth Hormone Growth Hormone Deficiency Annual Growth Rate Human Growth Hormone Turner Syndrome
Unable to display preview. Download preview PDF.
- 13.Hutchings JJ, Escamilla RF, Li CH, Forsham PH. Li human growth hormone administration in gonadal dysgenesis. Am J Dis Child; 109: 318.Google Scholar
- 14.Tzagournis M. Response to long-term administration of human growth hormone in Turner’s syndrome. JAMA 1969; 210: 2373.Google Scholar
- 15.Tanner JM, Whitehouse RH, Hughes PCR, Vince FP. Effect of human growth hormone treatment for 1 to 7 years on growth of 100 children, with growth hormone deficiency, low birth weight, inherited smallness, Turner2019s syndrome and other complaints. Arch Dis Child 1971; 46: 745.PubMedCrossRefGoogle Scholar
- 20.Takano K, Hizuka N, Shizume K. Treatment of Turner’s syndrome with methionyl human growth hormone for six months. Acta Endocrinol (Copenh) 1986; 112: 130.Google Scholar
- 21.Takano K, Hizuka N, Shizume K. Growth hormone treatment in Turner’s syndrome. Acta Paediatr Scand [Suppl] 1986; 325:58Google Scholar
- 25.Almqvist S, Hall K, Lindstedt S, Lindsten J, Luft R, Sjoberg HE. Effects of short term administration of physiological doses of human growth hormone in three patients with Turner's syndrome. Acta Endocrinol (Copenh) 1964; 46: 451.Google Scholar