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Growth Hormone Therapy in Turner’s Syndrome

  • Ron G. Rosenfeld
  • Raymond L. Hintz
  • Ann J. Johanson
  • Barry Sherman
  • the Genentech Collaborative Group
Part of the Serono Symposia, USA book series (SERONOSYMP)

Abstract

The estimated incidence of Turner’s syndrome in live-born, phenotypic females varies between 1/2,000 and 1/10,000 (1). As such, it is a major cause of growth retardation, and, in many pediatric endocrine centers, is as common a diagnosis as classical growth hormone deficiency. Although significant variability in phenotypic expression exists, all major reviews of spontaneous growth in Turner’s syndrome demonstrate significant reduction in final adult heights (2–7). In Ranke’s 1983 review of growth in German girls with Turner’s syndrome (7), final adult height averaged 146.8 cm (-2.57 standard deviations), while previous reviews reported mean adult heights ranging from 140.2–146.3 cm.

Keywords

Growth Hormone Growth Hormone Deficiency Annual Growth Rate Human Growth Hormone Turner Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Ron G. Rosenfeld
    • 1
    • 2
  • Raymond L. Hintz
    • 1
    • 2
  • Ann J. Johanson
    • 1
    • 2
  • Barry Sherman
    • 1
    • 2
  • the Genentech Collaborative Group
    • 1
    • 2
  1. 1.Department of PediatricsStanford University Medical CenterStanfordUSA
  2. 2.Genentech, Inc.South San FranciscoUSA

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