Growth Hormone Therapy in Turner’s Syndrome

  • Ron G. Rosenfeld
  • Raymond L. Hintz
  • Ann J. Johanson
  • Barry Sherman
  • the Genentech Collaborative Group
Part of the Serono Symposia, USA book series (SERONOSYMP)


The estimated incidence of Turner’s syndrome in live-born, phenotypic females varies between 1/2,000 and 1/10,000 (1). As such, it is a major cause of growth retardation, and, in many pediatric endocrine centers, is as common a diagnosis as classical growth hormone deficiency. Although significant variability in phenotypic expression exists, all major reviews of spontaneous growth in Turner’s syndrome demonstrate significant reduction in final adult heights (2–7). In Ranke’s 1983 review of growth in German girls with Turner’s syndrome (7), final adult height averaged 146.8 cm (-2.57 standard deviations), while previous reviews reported mean adult heights ranging from 140.2–146.3 cm.


Growth Hormone Growth Hormone Deficiency Annual Growth Rate Human Growth Hormone Turner Syndrome 
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  1. 1.
    Gerald PS. Sex chromosome disorders. N Engl J Med 1976; 294: 706.PubMedCrossRefGoogle Scholar
  2. 2.
    Palmer CG, Reichmann A. Chromosomal and clinical findings in 110 females with Turner syndrome. Hum Genet 1976; 35: 35.PubMedCrossRefGoogle Scholar
  3. 3.
    Park E, Bailey JD, Cowell CA. Growth and maturation of patients with Turner’s syndrome. Pediatr Res 1983; 17: 1.PubMedCrossRefGoogle Scholar
  4. 4.
    Brook CGD, Murset G, Zachmann M, Prader A. Growth in children with 45,XO Turner’s syndrome. Arch Dis Child 1974; 49: 789.PubMedCrossRefGoogle Scholar
  5. 5.
    Lev-Ran A. Androgens, estrogens, and the ultimate height in XO gonadal dysgenesis. Am J Dis Child 1977; 131: 648.PubMedGoogle Scholar
  6. 6.
    Sybert VP. Adult height in Turner syndrome with and without androgen therapy. J Pediatr 1984; 104: 365.PubMedCrossRefGoogle Scholar
  7. 7.
    Ranke MB, Pfluger H, Rosendahl W, et al. Turner syndrome: spontaneous growth in 150 cases and review of the literature. Eur J Pediatr 1983; 141: 81.PubMedCrossRefGoogle Scholar
  8. 8.
    Urban MD, Lee PA, Dorst JP, Plotnick LP, Migeon CJ. Oxandrolone therapy in patients with Turner syndrome. J Pediatr 1979; 94: 823.PubMedCrossRefGoogle Scholar
  9. 9.
    Lenko HL, Perheentupa J, Soderholm A. Growth in Turner’s syndrome: spontaneous and fluoxymesterone stimulated. Acta Paediatr Scand [Suppl] 1979; 277: 57.CrossRefGoogle Scholar
  10. 10.
    Joss E, Zuppinger K. Oxandrolone in girls with Turner’s syndrome: a pair-matched controlled study up to final height. Acta Paediatr Scand 1984; 73: 674.PubMedCrossRefGoogle Scholar
  11. 11.
    Soyka LF, Ziskind A, Crawford JD. Treatment of short stature in children and adolescents with human pituitary hormone (Raben). N Engl J Med 1964; 271: 754.PubMedCrossRefGoogle Scholar
  12. 12.
    Wright JC, Brasel JA, Aceto T Jr, et al. Studies with human growth hormone. Am J Med 1965; 38: 499.PubMedCrossRefGoogle Scholar
  13. 13.
    Hutchings JJ, Escamilla RF, Li CH, Forsham PH. Li human growth hormone administration in gonadal dysgenesis. Am J Dis Child; 109: 318.Google Scholar
  14. 14.
    Tzagournis M. Response to long-term administration of human growth hormone in Turner’s syndrome. JAMA 1969; 210: 2373.Google Scholar
  15. 15.
    Tanner JM, Whitehouse RH, Hughes PCR, Vince FP. Effect of human growth hormone treatment for 1 to 7 years on growth of 100 children, with growth hormone deficiency, low birth weight, inherited smallness, Turner2019s syndrome and other complaints. Arch Dis Child 1971; 46: 745.PubMedCrossRefGoogle Scholar
  16. 16.
    Rudman D, Goldsmith M, Kutner M, Blackston D. Effect of growth hormone and oxandrolone singly and together on growth rate in girls with X chromosome abnormalities. J Pediatr 1980; 96: 132.PubMedCrossRefGoogle Scholar
  17. 17.
    Butenandt O. Growth hormone deficiency and growth hormone therapy in Ullrich-Turner syndrome. Klin Wochenschr 1980; 58: 99.PubMedCrossRefGoogle Scholar
  18. 18.
    Stahnke N. Human growth hormone treatment in short children without growth hormone deficiency. N Engl J Med 1984; 310: 925.PubMedCrossRefGoogle Scholar
  19. 19.
    Singer-Granick C, Lee PA, Foley TP Jr, Becker DJ. Growth hormone therapy for patients with Turner’s syndrome. Horm Res 1986; 24: 246.PubMedCrossRefGoogle Scholar
  20. 20.
    Takano K, Hizuka N, Shizume K. Treatment of Turner’s syndrome with methionyl human growth hormone for six months. Acta Endocrinol (Copenh) 1986; 112: 130.Google Scholar
  21. 21.
    Takano K, Hizuka N, Shizume K. Growth hormone treatment in Turner’s syndrome. Acta Paediatr Scand [Suppl] 1986; 325:58Google Scholar
  22. 22.
    Raiti S, Moore WV, Van Vliet G, Kaplan SL, The National Hormone and Pituitary Program. Growth stimulating effects of human growth hormone therapy in patients with Turner syndrome. J Pediatr 1986; 109: 944.PubMedCrossRefGoogle Scholar
  23. 23.
    Rosenfeld RG, Hintz RL, Johanson AJ, et al. Methionyl human growth hormone and oxandrolone in Turner syndrome: preliminary results of a prospective randomized trial. J Pediatr 1986; 109: 936.PubMedCrossRefGoogle Scholar
  24. 24.
    Rosenfeld RG, Hintz RL, Johanson AJ, Sherman B, The Genentech Collaborative Group. Results from the first 2 years of a clinical trial with recombinant DNA-derived human growth hormone (Somatrem) in Turner’s syndrome. Acta Paediatr Scand [Suppl] 1987; 331: 59.CrossRefGoogle Scholar
  25. 25.
    Almqvist S, Hall K, Lindstedt S, Lindsten J, Luft R, Sjoberg HE. Effects of short term administration of physiological doses of human growth hormone in three patients with Turner's syndrome. Acta Endocrinol (Copenh) 1964; 46: 451.Google Scholar
  26. 26.
    Forbes AP, Jacobsen JG, Carroll EL, Pechet MM. Studies of growth arrest in gonadal dysgenesis: response to exogenous human growth hormone. Metabolism 1962; 11: 56.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Ron G. Rosenfeld
    • 1
    • 2
  • Raymond L. Hintz
    • 1
    • 2
  • Ann J. Johanson
    • 1
    • 2
  • Barry Sherman
    • 1
    • 2
  • the Genentech Collaborative Group
    • 1
    • 2
  1. 1.Department of PediatricsStanford University Medical CenterStanfordUSA
  2. 2.Genentech, Inc.South San FranciscoUSA

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