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Some Aspects on the Biochemistry of Growth Hormone

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Book cover Basic and Clinical Aspects of Growth Hormone

Part of the book series: Serono Symposia, USA ((SERONOSYMP))

Abstract

In 1921, Evans and Long (1) injected a saline extract of anterior lobes of bovine pituitaries into normal rats and the growth of these animals was accelerated. Later experiments by Smith in 1927 (2) showed that the growth of hypophysectomized rats was resumed on administration of the same anterior pituitary extract. Thus, the existence of growth- promoting activities in these extracts was indicated. In 1944, Li and Evans reported the isolation of a protein from bovine pituitary extracts with a molecular weight of 44,250 in solutions of pH 6.64-7.00 and an isoelectric point of pH 6.85 having growth-promoting activity in hypophysectomized rats and devoid of other pituitary hormone activities (3,4). The protein was identified as the growth hormone (GH) of bovine pituitary gland or bGH.

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Authors and Affiliations

  1. Laboratory of Molecular Endocrinology, University of California, San Francisco, CA, 94143, USA

    Choh Hao Li

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  1. Choh Hao Li
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Editor information

Editors and Affiliations

  1. University of South Florida, Tampa, Florida, USA

    Barry B. Bercu

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© 1988 Plenum Press, New York

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Li, C.H. (1988). Some Aspects on the Biochemistry of Growth Hormone. In: Bercu, B.B. (eds) Basic and Clinical Aspects of Growth Hormone. Serono Symposia, USA. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5505-2_3

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  • DOI: https://doi.org/10.1007/978-1-4684-5505-2_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5507-6

  • Online ISBN: 978-1-4684-5505-2

  • eBook Packages: Springer Book Archive

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