Some Aspects on the Biochemistry of Growth Hormone

  • Choh Hao Li
Part of the Serono Symposia, USA book series (SERONOSYMP)


In 1921, Evans and Long (1) injected a saline extract of anterior lobes of bovine pituitaries into normal rats and the growth of these animals was accelerated. Later experiments by Smith in 1927 (2) showed that the growth of hypophysectomized rats was resumed on administration of the same anterior pituitary extract. Thus, the existence of growth- promoting activities in these extracts was indicated. In 1944, Li and Evans reported the isolation of a protein from bovine pituitary extracts with a molecular weight of 44,250 in solutions of pH 6.64-7.00 and an isoelectric point of pH 6.85 having growth-promoting activity in hypophysectomized rats and devoid of other pituitary hormone activities (3,4). The protein was identified as the growth hormone (GH) of bovine pituitary gland or bGH.


Growth Hormone Pituitary Growth Hormone Bovine Growth Hormone Single Base Mutation Pept Protein 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Choh Hao Li
    • 1
  1. 1.Laboratory of Molecular EndocrinologyUniversity of CaliforniaSan FranciscoUSA

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