Abstract
Although human growth hormone (hGH) has been administered to growth hormone deficient patients for over 25 years (1), minimal data has been published on the relationship of dose to response. This paper will review the dose-response information which is now available for pituitary hGH, based on data derived from the initial year of treatment in growth hormone deficient patients.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Raben MS. Treatment of a pituitary dwarf with human growth hormone. J Clin Endocrinol Metab 1958; 18: 901–3.
Rosenbloom AL. Growth hormone replacement therapy. JAMA 1966; 198: 364–8.
Frasier SD, Aceto I, Kayles AB, Mikit-y VG. Collaborative study of the effects of human growth hormone in growth hormone deficiency; IV. Treatment with low doses of human growth hormone based on body weight. J Clin Endocrinol Metab 1977; 44: 22–31.
Preece MA, Tanner JM, Whitehouse RH, Cameron N. Dose dependence of growth response to human growth hormone in growth hormone deficiency. J Clin Endocrinol Metab 1976; 42: 477–83.
Milner RDG, Rusell-Fraser T, Brook CGD, et al. Experience with human growth hormone in Great Britain: the report of the MRC working party. Clin Endocrinol (Oxf) 1979; 11: 15–38.
Aceto T, Frasier SD, Hayles AB, et al. Collaborative study of effects of human growth hormone in growth hormone deficiency. I. First year of therapy. J Clin Endocrinol Metab 1972; 35: 483–96.
Guyda H, Friesen H, Bailey JD, Leboeuf G, Beck JC. Medical Research Council of Canada therapeutic trial of human growth hormone: first 5 years of therapy. Can Med Assoc J 1975; 112: 1301–9.
Vicens-Calvet E, Vendrell JM, Albisu M, Potau N, Audi L, Gusine M. The dosage dependency of growth and the maturity in growth hormone deficiency treated with human growth hormone. Acta Paediatr Scand 1984; 73: 120–6.
Frasier SD, Costin G, Lippe BM, Aceto T, Bunger PF. A dose-response curve for human growth hormone. J Clin Endocrinol Metab 1981; 53: 1213–7.
Frasier SD. The serum growth-hormone response to hypoglycemia in dwarfism. J Pediatr 1967; 71: 625–38.
Parker ML, Hammond JM, Daughaday WH. The arginine provocative test: an aid in the diagnosis of hyposomatotropism. J Clin Endocrinol Metab 1967; 27: 1129–36.
Penny R, Blizzard RM, Davis WT. Sequential-arginine and insulin tolerance tests on the same day. J Clin Endocrinol Metab 1967; 29: 1499–501.
Swincoe TDV. Statistics at square one. London: British Medical Association, 1978.
Bliss CI. The statistics of bioassay with special reference to the vitamins. New York: Academic Press, 1952: 452–71.
Rudman D, Kutner MH, Fleming GA, et al. Effect of 10-day courses of human growth hormone on height of short children. J Clin Endocrinol Metab 1978; 46: 28–35.
Rudman D, Chyatte SB, Patterson JHy et al. Observations on the responsiveness of human subjects to human growth hormone. Effects of endogenous growth hormone deficiency and myotonic dystrophy. J Clin Invest 1971; 50: 1941–9.
Nugent JN, Moore DC, Ruvalcaba RHA, Kelley VC. Dose response curve for human growth hormone and oxandrolone by weight in children with hypopituitarism. Clin Res 1981; 29: 111A.
Kaplan SL. Clinical trial of protropin. Meeting of the Endocrinologie and Metabolic Drug Advisory Committee Food and Drug Administration, Bethseda, MD, September 10–11, 1984.
Kaplan SL, Underwood LE, August GP, et al. Clinical studies with recombinant-DNA-derived methionyl human growth hormone in growth hormone deficient children. Lancet 1986; 1: 697–700.
Kaplan SL, Underwood LE, August GP, et al. Clinical studies with recombinant-DNA-derived methionyl-human growth hormone in growth hormone-deficient children. In: Raiti S, Tolman RA, eds. Human growth hormone. New York: Plenum Medical Book Company, 1986: 267–77.
Gertner JM, Tamborlane WV, Gianfredi SP, Genel M. Renewed catch-up growth with increased replacement doses of human growth hormone. J Pediatr 1987; 110: 425–8.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Plenum Press, New York
About this chapter
Cite this chapter
Frasier, S.D. (1988). Dose-Response Relationship of Growth Hormone Therapy. In: Bercu, B.B. (eds) Basic and Clinical Aspects of Growth Hormone. Serono Symposia, USA. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5505-2_28
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5505-2_28
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5507-6
Online ISBN: 978-1-4684-5505-2
eBook Packages: Springer Book Archive