Dose-Response Relationship of Growth Hormone Therapy

  • S. Douglas Frasier
Part of the Serono Symposia, USA book series (SERONOSYMP)


Although human growth hormone (hGH) has been administered to growth hormone deficient patients for over 25 years (1), minimal data has been published on the relationship of dose to response. This paper will review the dose-response information which is now available for pituitary hGH, based on data derived from the initial year of treatment in growth hormone deficient patients.


Growth Hormone Growth Velocity Growth Hormone Deficiency Human Growth Hormone International Unit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Raben MS. Treatment of a pituitary dwarf with human growth hormone. J Clin Endocrinol Metab 1958; 18: 901–3.PubMedCrossRefGoogle Scholar
  2. 2.
    Rosenbloom AL. Growth hormone replacement therapy. JAMA 1966; 198: 364–8.PubMedCrossRefGoogle Scholar
  3. 3.
    Frasier SD, Aceto I, Kayles AB, Mikit-y VG. Collaborative study of the effects of human growth hormone in growth hormone deficiency; IV. Treatment with low doses of human growth hormone based on body weight. J Clin Endocrinol Metab 1977; 44: 22–31.PubMedCrossRefGoogle Scholar
  4. 4.
    Preece MA, Tanner JM, Whitehouse RH, Cameron N. Dose dependence of growth response to human growth hormone in growth hormone deficiency. J Clin Endocrinol Metab 1976; 42: 477–83.PubMedCrossRefGoogle Scholar
  5. 5.
    Milner RDG, Rusell-Fraser T, Brook CGD, et al. Experience with human growth hormone in Great Britain: the report of the MRC working party. Clin Endocrinol (Oxf) 1979; 11: 15–38.CrossRefGoogle Scholar
  6. 6.
    Aceto T, Frasier SD, Hayles AB, et al. Collaborative study of effects of human growth hormone in growth hormone deficiency. I. First year of therapy. J Clin Endocrinol Metab 1972; 35: 483–96.PubMedCrossRefGoogle Scholar
  7. 7.
    Guyda H, Friesen H, Bailey JD, Leboeuf G, Beck JC. Medical Research Council of Canada therapeutic trial of human growth hormone: first 5 years of therapy. Can Med Assoc J 1975; 112: 1301–9.PubMedGoogle Scholar
  8. 8.
    Vicens-Calvet E, Vendrell JM, Albisu M, Potau N, Audi L, Gusine M. The dosage dependency of growth and the maturity in growth hormone deficiency treated with human growth hormone. Acta Paediatr Scand 1984; 73: 120–6.PubMedCrossRefGoogle Scholar
  9. 9.
    Frasier SD, Costin G, Lippe BM, Aceto T, Bunger PF. A dose-response curve for human growth hormone. J Clin Endocrinol Metab 1981; 53: 1213–7.PubMedCrossRefGoogle Scholar
  10. 10.
    Frasier SD. The serum growth-hormone response to hypoglycemia in dwarfism. J Pediatr 1967; 71: 625–38.PubMedCrossRefGoogle Scholar
  11. 11.
    Parker ML, Hammond JM, Daughaday WH. The arginine provocative test: an aid in the diagnosis of hyposomatotropism. J Clin Endocrinol Metab 1967; 27: 1129–36.PubMedCrossRefGoogle Scholar
  12. 12.
    Penny R, Blizzard RM, Davis WT. Sequential-arginine and insulin tolerance tests on the same day. J Clin Endocrinol Metab 1967; 29: 1499–501.CrossRefGoogle Scholar
  13. 13.
    Swincoe TDV. Statistics at square one. London: British Medical Association, 1978.Google Scholar
  14. 14.
    Bliss CI. The statistics of bioassay with special reference to the vitamins. New York: Academic Press, 1952: 452–71.Google Scholar
  15. 15.
    Rudman D, Kutner MH, Fleming GA, et al. Effect of 10-day courses of human growth hormone on height of short children. J Clin Endocrinol Metab 1978; 46: 28–35.PubMedCrossRefGoogle Scholar
  16. 16.
    Rudman D, Chyatte SB, Patterson JHy et al. Observations on the responsiveness of human subjects to human growth hormone. Effects of endogenous growth hormone deficiency and myotonic dystrophy. J Clin Invest 1971; 50: 1941–9.PubMedCrossRefGoogle Scholar
  17. 17.
    Nugent JN, Moore DC, Ruvalcaba RHA, Kelley VC. Dose response curve for human growth hormone and oxandrolone by weight in children with hypopituitarism. Clin Res 1981; 29: 111A.Google Scholar
  18. 18.
    Kaplan SL. Clinical trial of protropin. Meeting of the Endocrinologie and Metabolic Drug Advisory Committee Food and Drug Administration, Bethseda, MD, September 10–11, 1984.Google Scholar
  19. 19.
    Kaplan SL, Underwood LE, August GP, et al. Clinical studies with recombinant-DNA-derived methionyl human growth hormone in growth hormone deficient children. Lancet 1986; 1: 697–700.PubMedCrossRefGoogle Scholar
  20. 20.
    Kaplan SL, Underwood LE, August GP, et al. Clinical studies with recombinant-DNA-derived methionyl-human growth hormone in growth hormone-deficient children. In: Raiti S, Tolman RA, eds. Human growth hormone. New York: Plenum Medical Book Company, 1986: 267–77.CrossRefGoogle Scholar
  21. 21.
    Gertner JM, Tamborlane WV, Gianfredi SP, Genel M. Renewed catch-up growth with increased replacement doses of human growth hormone. J Pediatr 1987; 110: 425–8.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • S. Douglas Frasier
    • 1
  1. 1.Department of PediatricsOlive View Medical CenterSylmarUSA

Personalised recommendations