Improvement in Growth Rate and Mean Predicted Height during Long-Term Treatment with Growth Hormone in Children with Non-Growth Hormone Deficient Short Stature

  • Selna L. Kaplan
Part of the Serono Symposia, USA book series (SERONOSYMP)


Children with short stature, a normal RIA GH response to provocative stimuli, delayed bone age and a decreased growth rate for age comprise a heterogenous group (1–7). An inadequate growth rate in prepubertal children suggests deficits of growth promoting factors and/or hormones or the inability to respond to them (8–20). The term “short normal” children is an inappropriate designation for these children.


Growth Hormone Short Stature Human Growth Hormone Growth Hormone Treatment Short Child 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Kaplan SL, Abrams CAL, Bell JJ, Conte FA, Grumbach MM. I. Changes in serum level of growth hormone following hypoglycemia in 134 children with growth retardation. Pediatr Res 1960; 2: 43–63.CrossRefGoogle Scholar
  2. 2.
    Grunt JA, Enriquez AP. Acute and long-term responsiveness to growth hormone in children with short stature. Pediatr Res 1972; 6: 664–74.PubMedCrossRefGoogle Scholar
  3. 3.
    Rudman D, Kutner MH, Blackston RD, Jansen RD, Patterson JH. Normal variant short stature: subclassification based on responses to exogenous human growth hormone. J Clin Endocrinol Metab 1979; 49: 92–9.PubMedCrossRefGoogle Scholar
  4. 4.
    Lenko HL, Leisti S, Perheentupa J. The efficacy of growth hormone in different types of growth failures: analysis of 101 cases. Eur J Pediatr 1982; 138: 241–9.PubMedCrossRefGoogle Scholar
  5. 5.
    Tanner JM, Whitehouse RH, Hughes PCR, Vince FP. Effect of human growth hormone treatment for 1 to 7 years on growth of 100 children with growth hormone deficiency, low birth weight, inherited smallness, Turner’s syndrome and other complaints. Arch Dis Child 1971; 46: 745–82.PubMedCrossRefGoogle Scholar
  6. 6.
    Van Vliet G, Styne DM, Kaplan SL, Grumbach MM. Growth hormone treatment for short stature. N Engl J Med 1983; 309: 1016–22.PubMedCrossRefGoogle Scholar
  7. 7.
    Plotnick LP, Van Meter QL, Kowarski AA. Human growth hormone treatment of children with growth failure and normal growth hormone levels by immunoassay. Pediatrics 1983; 71: 324–7.PubMedGoogle Scholar
  8. 8.
    Grunt JA, Howard C, Daughaday WH. Comparison of growth and somatomedin responses following growth hormone treatment in children with small-for-date short stature, significant idiopathic short stature, and hypopituitarism. Acta Endocrinol (Copenh) 1984; 106: 168–74.Google Scholar
  9. 9.
    Wise PH, Burnet RB, Geary TD, Berriman H. Selective impairment of growth hormone response to pharmacological tests. Arch Dis Child 1975; 50: 210–4.PubMedCrossRefGoogle Scholar
  10. 10.
    Cacciari E, Coccagna G, Cicognani A, et al. Growth hormone release during sleep in growth-retarded children with normal response to pharmacological tests. Arch Dis Child 1978; 53: 487–90.PubMedCrossRefGoogle Scholar
  11. 11.
    Plotnick LP, Lee PA, Migeon CJ, Kowarski AA. Comparison of physiological and pharmacological tests of growth hormone function in children with short statute. J Clin Endocrinol Metab 1979; 48: 811–5.PubMedCrossRefGoogle Scholar
  12. 12.
    Spiliotis B, August G, Hung W, Sonis W, Mendelson W, Bercu BB. Growth hormone neurosecretory dysfunction: a treatable cause of short stature. JAMA 1984; 251: 2223–30.PubMedCrossRefGoogle Scholar
  13. 13.
    Siegel SF, Beeker DJ, Lee PH, Gutai JP, Foley TP, Drash AL. Comparison of physiologic and pharmacologic assessment of growth hormone secretion. Am J Dis Child 1984; 138: 540–3.PubMedGoogle Scholar
  14. 14.
    Bercu BB, Shulman D, Root AW, Spiliotis BE. Growth hormone provocative testing frequently does not reflect endogenous growth hormone secretion. J Clin Endocrinol Metab 1986; 63: 709–16.PubMedCrossRefGoogle Scholar
  15. 15.
    Frazier TE, Gavin JR, Daughaday WH, Hillman RE, Weldon W. Growth hormone-dependent growth failure. J Pediatr 1982; 101: 12–5.CrossRefGoogle Scholar
  16. 16.
    Blethen SL, Chasalow FI. Use of a two-site immunoradiometric assay for growth hormone (GH) in identifying children with GH dependent growth failure. J Clin Endocrinol Metab 1983; 57: 1031–5.PubMedCrossRefGoogle Scholar
  17. 17.
    Tokuhiro E, Dean HJ, Friesen HG, Rudman D. Comparative study of serum human growth measurements with NB2 lymphoma cell bioassay, IM-9 receptor modulation assay and radioimmunoassay in children with disorders of growth. J Clin Endocrinol Metab 1984; 58: 549–54.PubMedCrossRefGoogle Scholar
  18. 18.
    Kowarski AA, Schnieder J, Ben-Balim E, Weldon VV, Daughaday WH. Growth failure with normal serum RIA-GH and low somatomedin activity: somatomedin restoration and growth acceleration after exogenous GH. J Clin Endocrinol Metab 1978; 47: 461–4.PubMedCrossRefGoogle Scholar
  19. 19.
    Valenta LJ, Siegel MB, Lesniak MA, et al. Pituitary dwarfism in a patient with circulating abnormal growth hormone polymers. N Engl J Med 1985; 312: 214–7.PubMedCrossRefGoogle Scholar
  20. 20.
    Lanes P, Plotnick LP, Spencer ME, Daughaday WH, Kowarski AA. Dwarfism associated with normal serum growth hormone and increase bioassayable receptorassayable and immunoassayable somatomedin. J Clin Endocrinol Metab 1980; 50: 485–8.PubMedCrossRefGoogle Scholar
  21. 21.
    Gertner JM, Genel M, Gianfredi SP, et al. Prospective clinical trial of human growth hormone in short children without growth hormone deficiency. J Pediatr 1984; 104: 172–6.PubMedCrossRefGoogle Scholar
  22. 22.
    Bayley N, Pinneau SR. Tables for predicting adult height from skeletal age: revised for uce with Greulich-Pyle hand standards. J Pediatr 1952; 40: 423–41.Google Scholar
  23. 23.
    Roche AF, Wainer H, Thissen D. The RWT method for the prediction of adult stature. Pediatrics 1975; 56: 1026–33.Google Scholar
  24. 24.
    Tanner JM. Use and abuse of growth standards. In: Falkner F, Tanner JM, eds. Human growth; vol 3. New York: Plenum Press, 1986: 95–109.Google Scholar
  25. 25.
    Tanner JM, Whitehouse RH, Marshall WA, Carter BS. Prediction of adult height from height bone age and occurrence of menarche at ages 4 to 16 with allowance for midparent height. Arch Dis Child 1975; 50: 14–26.PubMedCrossRefGoogle Scholar
  26. 26.
    Zachman M, Sobradillo B, Frank M, Frisch H, Prader H. Bayley- Pinneau, Roche-Wainer-Thissen and Tanner height predictions in normal children and in patients with various pathologic conditions. J Pediatr 1978; 93: 749–55.CrossRefGoogle Scholar
  27. 27.
    Roche AF. Adult stature prediction: a critical review. Acta Med Auxol 1985; 16: 5–28.Google Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Selna L. Kaplan
    • 1
  1. 1.Department of PediatricsUniversity of CaliforniaSan FranciscoUSA

Personalised recommendations