Advertisement

Therapeutic Effects of Growth Hormone Releasing Hormone

  • A. D. Rogol
  • R. M. Blizzard
  • P. M. MarthaJr.
  • W. S. Evans
  • M. L. Vance
  • C. Brook
  • P. Smith
  • G. Klingensmith
  • I. Burr
  • J. Najjar
  • R. Furlanetto
  • J. Rivier
  • W. Vale
  • M. O. Thorner
Part of the Serono Symposia, USA book series (SERONOSYMP)

Abstract

The existence of hypothalamic-hypophyseal releasing factors was suggested by the pioneering work of Sir Geoffrey Harris (1); Reichlin and co-workers postulated that a specific releasing factor for growth hormone (GH) was present in the hypothalamus (2). Its isolation, purification, and synthesis followed more than three decades of intensive investigation and awaited many refinements in the fields of bioassay, analytic biochemistry and, most importantly, a rich source of the peptide free from “contamination” with somatostatin (SRIH).

Keywords

Growth Hormone Growth Hormone Level Growth Hormone Response Serum Growth Hormone Growth Hormone Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Green JD, Harris GW. The neurovascular link between the neurohypophysis and adenohypophysis. J Endocrinol 1947; 5: 136.PubMedCrossRefGoogle Scholar
  2. 2.
    Reichlin S. Growth hormone content of pituitaries from rats with hypothalamic lesions. Endocrinology 1961; 69: 225.PubMedCrossRefGoogle Scholar
  3. 3.
    Thorner MO, Perryman RL, Cronin MJ, et al. Somatotroph hyperplasia: successful treatment of acromegaly by removal of a pancreatic tumor secreting a growth releasing factor. J Clin Invest 1982; 70: 965.PubMedCrossRefGoogle Scholar
  4. 4.
    Rivier J, Spiess J, Thorner M, Vale W. Sequence analysis of a growth hormone releasing factor from a human pancreatic islet tumor. Biochemistry 1982; 24: 6037.Google Scholar
  5. 5.
    Guilleman R, Brazeau P, Bohlen P, et al. Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly. Science 1982; 218: 585.CrossRefGoogle Scholar
  6. 6.
    Bohlen P, Brazeau P, Block B, et al. Human hypothalamic growth hormone-releasing factor (GRF): evidence for two forms identical to tumor derived GRF-44-NH and GRF-40. Biochem Biophys Res Commun 1983; 114: 930.PubMedCrossRefGoogle Scholar
  7. 7.
    Mayo KE, Vale W, Rivier J, et al. Expression cloning and sequence of cDNA encoding human growth hormone-releasing factor. Nature 1983; 306: 86.PubMedCrossRefGoogle Scholar
  8. 8.
    Tannenbaum GS. Growth hormone-releasing factor: direct effects on growth hormone, glucose and behavior via the brain. Science 1984; 226: 464.PubMedCrossRefGoogle Scholar
  9. 9.
    Tannenbaum GS, Guyda HJ, Posner BI. Insulin-like growth factors: a role in growth hormone negative feedback and body weight regulation via the brain. Science 1983; 220: 77.PubMedCrossRefGoogle Scholar
  10. 10.
    Berelowitz M, Szabo M, Frohman LA, Firestone S, Chu L, Hintz RL. Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary. Science 1981; 212: 1279.PubMedCrossRefGoogle Scholar
  11. 11.
    Thorner M, Rivier J, Spiess J, et al. Human pancreatic growth- hormone-releasing factor selectively stimulates growth-hormone secretion in man. Lancet 1983; 1: 24.PubMedCrossRefGoogle Scholar
  12. 12.
    Vance M, Borges J, Kaiser D, et al. Human pancreatic tumor growth hormone releasing factor (hpGRF-40): dose response relationships in normal man. J Clin Endocrinol Metab 1984; 58: 838.PubMedCrossRefGoogle Scholar
  13. 13.
    Evans WS, Borges JLC, Vance ML, et al. Effect of human pancreatic growth hormone-releasing factor-40 on serum growth hormone, prolactin, luteinizing hormone, follicle-stimulating hormone, and somatomedin-C concentrations in normal women throughout the menstrual cycle. J Clin Endocrinol Metab 1984; 59: 1006.PubMedCrossRefGoogle Scholar
  14. 14.
    Rogol AD, Blizzard RM, Johanson AJ, et al. Growth hormone release in response to human pancreatic tumor growth hormone-releasing factor-40 in children with short stature. J Clin Endocrinol Metab 1984; 59: 580.PubMedCrossRefGoogle Scholar
  15. 15.
    Takano K, Hizuka N, Shizume K, et al. Plasma growth hormone (GH) response to GH-releasing factor in normal children with short stature and patients with pituitary dwarfism, J Clin Endocrinol Metab 1984; 58: 236.PubMedCrossRefGoogle Scholar
  16. 16.
    Borges J, Blizzard R, Gelato M, et al. Effects of human pancreatic growth hormone releasing factor on growth hormone and somatomedin C levels in patients with idiopathic growth hormone deficiency. Lancet 1983; ii:119.CrossRefGoogle Scholar
  17. 17.
    Borges J, Blizzard R, Evans W, et al. Stimulation of growth hormone (GH) and somatomedin C in idiopathic GH-deficient subjects by intermittent pulsatile administration of synthetic human pancreatic tumor GH-releasing factor. J Clin Endocrinol Metab 1984; 59: 1.PubMedCrossRefGoogle Scholar
  18. 18.
    Rogol AD, Blizzard RM, Foley TP Jr, et al. Growth hormone releasing hormone and growth hormone: genetic studies in familial growth hormone deficiency. Pediatr Res 1985; 19: 489.PubMedCrossRefGoogle Scholar
  19. 19.
    Thorner M, Reschke J, Chitwood J, et al. Acceleration of growth in two children treated with human growth hormone releasing factor. N Engl J Med 1985; 312: 4.PubMedCrossRefGoogle Scholar
  20. 20.
    Spiliotis B, August G, Hung W, Sonis W, Mendelsohn W, Bercu BB. Growth hormone neurosecretory dysfunction: a treatable cause of short stature. JAMA 1984; 152: 2223.Google Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • A. D. Rogol
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
  • R. M. Blizzard
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
  • P. M. MarthaJr.
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
  • W. S. Evans
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
  • M. L. Vance
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
  • C. Brook
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
  • P. Smith
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
  • G. Klingensmith
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
  • I. Burr
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
  • J. Najjar
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
  • R. Furlanetto
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
  • J. Rivier
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
  • W. Vale
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
  • M. O. Thorner
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
  1. 1.University of Virginia Medical CenterCharlottesvilleUSA
  2. 2.The Middlesex HospitalLondonEngland
  3. 3.The Children’s Hospital School of MedicineUniversity of ColoradoDenverUSA
  4. 4.School of MedicineVanderbilt UniversityNashvilleUSA
  5. 5.Children’s Hospital of PhiladelphiaUSA
  6. 6.The Clayton Foundation Laboratories of Peptide BiologySalk InstituteSan DiegoUSA

Personalised recommendations