Therapeutic Effects of Growth Hormone Releasing Hormone
The existence of hypothalamic-hypophyseal releasing factors was suggested by the pioneering work of Sir Geoffrey Harris (1); Reichlin and co-workers postulated that a specific releasing factor for growth hormone (GH) was present in the hypothalamus (2). Its isolation, purification, and synthesis followed more than three decades of intensive investigation and awaited many refinements in the fields of bioassay, analytic biochemistry and, most importantly, a rich source of the peptide free from “contamination” with somatostatin (SRIH).
KeywordsGrowth Hormone Growth Hormone Level Growth Hormone Response Serum Growth Hormone Growth Hormone Concentration
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- 4.Rivier J, Spiess J, Thorner M, Vale W. Sequence analysis of a growth hormone releasing factor from a human pancreatic islet tumor. Biochemistry 1982; 24: 6037.Google Scholar
- 13.Evans WS, Borges JLC, Vance ML, et al. Effect of human pancreatic growth hormone-releasing factor-40 on serum growth hormone, prolactin, luteinizing hormone, follicle-stimulating hormone, and somatomedin-C concentrations in normal women throughout the menstrual cycle. J Clin Endocrinol Metab 1984; 59: 1006.PubMedCrossRefGoogle Scholar
- 20.Spiliotis B, August G, Hung W, Sonis W, Mendelsohn W, Bercu BB. Growth hormone neurosecretory dysfunction: a treatable cause of short stature. JAMA 1984; 152: 2223.Google Scholar