Assessing Selected Aspects of Adequacy of the Growth Hormone-Somatomedin Axis in Short Children with Quantitatively Normal Growth Hormone Secretion
Conventional approaches for confirming growth hormone adequacy in children with growth failure are the subject of considerable current debate. There is general agreement that individuals who fail repeatedly to secrete growth hormone in response to pharmacological provocation are growth hormone deficient. However, there is no uniform opinion concerning the diagnosis of, or even the presence of, lesser degrees of growth hormone insufficiency including those which might result from structurally abnormal molecules, defects at the growth hormone receptor/postreceptor levels, ineffective mutant somatomedins, or defective IGF-1 receptor/postreceptor signal transduction at the cellular level.
KeywordsGrowth Hormone Growth Hormone Deficiency Human Growth Hormone Growth Hormone Receptor Short Child
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