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Insulin-Like Growth Factors in Fetal Growth

  • Matthew M. Rechler
  • Yvonne W-H. Yang
  • Alexandra L. Brown
  • Joyce A. Romanus
  • Sallie O. Adams
  • Wieland Kiess
  • S. Peter Nissley
Part of the Serono Symposia, USA book series (SERONOSYMP)

Abstract

The insulin-like growth factors, IGF-I and IGF-II, are single-chain polypeptides chemically related to insulin that are synthesized in multiple fetal and adult tissues, and stimulate DMA synthesis and cell differentiation (1,2). IGF-I is regulated by growth hormone and nutritional factors, and promotes bone elongation in childhood (2). Based on results initially obtained in rats, IGF-II was proposed to play a role in fetal growth and development. This paper will review some of the evidence in support of this hypothesis, and discuss its applicability to human fetal development.

Keywords

Human Amniotic Fluid 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Matthew M. Rechler
    • 1
  • Yvonne W-H. Yang
    • 1
  • Alexandra L. Brown
    • 1
  • Joyce A. Romanus
    • 1
  • Sallie O. Adams
    • 1
  • Wieland Kiess
    • 1
  • S. Peter Nissley
    • 1
  1. 1.National Institutes of HealthBethesdaUSA

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