Biological Action of Insulin-Like Growth Factor-I In Vivo
It has been well known that somatomedin-C/insulin-like growth factor-I (SmC/IGF-I) stimulates cell proliferation and cell differentiation and an insulin-like action in vitro (1). However, there have been only a few reports on the effects of SmC/IGF-I in vivo because of scarcity of pure extracted SmC/IGF-I (2–4). Recently, insulin-like growth factor-I (IGF-I) has been synthesized by recombinant DNA technology (5–7). With the availability of large quantities of the biosynthetic IGF-I, the biological effects of IGF-I in vivo in rats have been studied (8–12). In this paper, the results of our study for biological action of IGF-I in vivo are reported.
KeywordsCholesterol Urea Streptozotocin Strepto
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