Chronobiology of Growth Hormone Secretion
The secretion of growth hormone (GH) in man occurs in episodic bursts during day and night (1). During trough periods, concentrations are below the sensitivity of the usual radioimmunoassay (approximately 0.5-1.0 ng/ml). Peak concentrations are often around 20 ng/ml, but may attain 50 ng/ml (or even more), especially in younger subjects. In man, the secretory episodes occur approximately every 4 h. Although some of these GH peaks are often missing in 24-h profiles, the rhythmicity probably persists with low-amplitude peaks occurring below the sensitivity of most current assay systems (2).
KeywordsGrowth Hormone Sleep Deprivation Growth Hormone Secretion Sleep Stage Growth Hormone Peak
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