Age and Sex-Related Neurosecretion of Growth Hormone

  • W. S. Evans
  • K. Y. Ho
  • A. C. S. Faria
  • R. J. KriegJr.
  • P. M. MarthaJr.
  • D. A. Leong
  • A. D. Rogol
  • J. D. Veldhuis
  • R. M. Blizzard
  • M. O. Thorner
Part of the Serono Symposia, USA book series (SERONOSYMP)


Although it has long been recognized that the secretion of growth hormone (GH) is influenced by age and sex, the mechanisms through which these factors mediate their effects remain incompletely understood. Indeed, and as is discussed below, in addition to the major gaps in our knowledge, there are numerous inconsistencies in the literature concerning issues which would seem to lend themselves to straightforward experimental approaches. We are of the opinion that much of the confusion in the literature reflects a failure to keep one premise clearly in mind: both age and sex almost certainly have both independent and interrelated effects on GH secretion. Thus, any experimental design utilized to examine issues related to GH secretion must include proper controls to account for these combined influences; failure to do so may and almost surely has provided discordant results. In addition, and although there are many factors which have prompted extensive use of the laboratory rat to address both in vivo and in vitro questions related to the secretion of GH, it must be emphasized that certain GH secretory dynamics in the rat vary markedly from those in the human; e.g., while stress and fasting have a positive effect on GH secretion in the human, they exert strongly negative influences in the rat. With these caveats having been mentioned, we now review briefly the literature concerning the effects of age and sex on the secretion of GH in the rat and human and subsequently discuss some recent observations which have resulted from our combined clinical and basic science research efforts focused on these issues.


Growth Hormone Growth Hormone Secretion Growth Hormone Level Growth Hormone Pulse Reverse Hemolytic Plaque Assay 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • W. S. Evans
    • 1
  • K. Y. Ho
    • 1
  • A. C. S. Faria
    • 1
  • R. J. KriegJr.
    • 2
  • P. M. MarthaJr.
    • 3
  • D. A. Leong
    • 1
  • A. D. Rogol
    • 3
  • J. D. Veldhuis
    • 1
  • R. M. Blizzard
    • 3
  • M. O. Thorner
    • 1
  1. 1.Department of Internal MedicineUniversity of Virginia Medical SchoolCharlottesvilleUSA
  2. 2.Department of PediatricsUniversity of Virginia Medical SchoolCharlottesvilleUSA
  3. 3.Department of Anatomy, Medical College of VirginiaVirginia Commonwealth UniversityRichmondUSA

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