Growth Hormone Neurosecretory Dysfunction: Update

  • Barry B. Bercu
Part of the Serono Symposia, USA book series (SERONOSYMP)


The neuroregulation of GH secretion is complex involving the dual regulatory control of a GH releasing hormone (GHRH) and GH inhibiting hormone (somatostatin or SRIH) (see Figures 1 and 2). These neurohormones are further regulated by neurotransmitters (Fig. 1). Experimental evidence (animal and human) for anatomic distribution and the possible role of neurotransmitters (dopaminergic, catecholaminergic, cholinergic, serotonergic, histaminergic, gama-aminobutyric acidergic) are reviewed in greater detail elsewhere (1,2). We hypothesize that defects in the neuro- regulatory control of GH secretion results in decreased or disordered GH secretion which is, ultimately, expressed as poor growth velocity and short stature.


Growth Hormone Growth Hormone Secretion Provocative Testing Peak Growth Hormone Idiopathic Short Stature 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Barry B. Bercu
    • 1
    • 2
  1. 1.Department of PediatricsUniversity of South Florida College of MedicineTampaUSA
  2. 2.All Children’s HospitalSt. PetersburgUSA

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