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The Release of Enkephalin-Containing Peptides from the Adrenal Gland in Conscious Calves

  • Jean Rossier
  • E. Barrès
  • A. Cupo
  • A. V. Edwards

Abstract

A number of recent studies have established the fact that enkephalins are released, together with catecholamines, from the adrenal medulla, both in vitro and in vivo in response to various stimuli (Kilpatrick et al., 1980; Stine et al., 1980; Livett et al., 1981; Hexum et al., 1980; Chaminade et al., 1984; Edwards et al., 1986). It further appears that these peptides are present in adrenergic, but not noradrenergic, chromaffin cells in the adrenal medulla (Livett et al., 1982; Pelto-Huikko et al., 1982; Roisin et al., 1983), but the functional significance of the phenomenon remains obscure.

Keywords

Adrenal Gland Chromaffin Cell Adrenal Medulla Splanchnic Nerve Bovine Adrenal Medulla 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bloom, S.R., Edwards, A.V., Hardy, R.N., Malinowska, K.W. and Silver, M.S., 1975, Endocrine responses to insulin hypoglycaemia in young calf, J. Phvsiol. (Lond.), 244: 783.Google Scholar
  2. Boarder, M.R., Evans, C., Adams, M., Erdelyi, E. and Barchas, J.D., 1987, Peptide E and its products, BAM 18 and Leu-enkephalin, in bovine adrenal medulla and cultured chromaffin cells: release in response to stimulation, J. Neurochem., in press.Google Scholar
  3. Chaminade, M., Foutz, A.S., and Rossier, J., 1984, Co-release of enkephalins and precursors with catecholamines from the perfused cat adrenal gland in situ, J. Phvsiol. (Lond.), 353: 157.Google Scholar
  4. Edwards, A.V., Hardy, R.N. and Malinowska, K.W., 1974, The effects of infusions of synthetic adrenocorticotrophin in the conscious calf, J. Phvsiol. (Lond.), 239: 477Google Scholar
  5. Edwards, A.V., Furness, P.N. and Helle, K.B., 1980, Adrenal medullary responses to stimulation of the splanchnic nerve in the conscious calf, J. Phvsiol. (Lond.), 308: 15.Google Scholar
  6. Edwards, A.V., Hansell, D., and Jones, C.T., 1986, Effects of synthetic adrenocorticotrophin on adrenal medullary responses to splanchnic nerve stimulation in conscious calves, J. Physiol. (Lond.), 379: 1.Google Scholar
  7. Euler, U.S. von and Floding, I., 1955, A fluorimetric micromethod for differential estimation of adrenaline and noradrenaline, Acta Physiol. Scand., 33, Suppl. 118: 45.Google Scholar
  8. Hexum, T.D., Hanbauer, I., Govoni, S., Yang, H.-Y.T., and Costa, E., 1980, Secretion of enkephalin-like peptides from canine adrenal gland following splanchnic nerve stimulation, Neuropeptides, 1: 137.CrossRefGoogle Scholar
  9. Kilpatrick, D.L., Lewis, R.V., Stein, S. and Udenfriend, S., 1980, Release of enkephalins and enkephalin-containing polypeptides from perfused beef adrenal glands, Proc. Natl. Acad. Sci. USA., 77: 7473.CrossRefGoogle Scholar
  10. Liston, D.R., Vanderhaeghen, J.J. and Rossier, J., 1983, Presence in brain of synenkephalin, a proenkephalin-immunoreactive protein which does not contain enkephalin, Nature, Lond, 302: 62.CrossRefGoogle Scholar
  11. Livett, B.G., Dean, D.M., Whelan, L.G., Udenfriend, S. and Rossier, J., 1981, Co-release of enkephalin and catecholamines from cultured adrenal chromaffin cells, Nature, Lond., 289: 317.CrossRefGoogle Scholar
  12. Livett, B.G., Day, R., Elde, R.P., and Howe, P.R.C., 1982, Co-storage of enkephalins and adrenaline in the bovine adrenal medulla, Neuroscience, 7: 13–23.Google Scholar
  13. Metters, K.M. and Rossier, J., 1984, Biosynthesis of the opioid peptides, In: Les Collogues de l’INSERM, Spinal opioids and the relief of pain. Edited by Besson, J.M. and Lazorthes, Y., INSERM 127: 31.Google Scholar
  14. Patey, G., Cupo, A., Mazarguil, H., Morgat, J.L. and Rossier, J., 1985, Release of proenkephalin-derived opioid peptides from rat striatum in vitro and their rapid degradation, Neuroscience, 15: 1035.CrossRefGoogle Scholar
  15. Pelto-Huikko, M., Salminen, T., and Hernoven, A., 1982, Enkephalin-like immunoreactivity is restricted to the adrenaline cells in the hamster adrenal medulla, Histochemistrv, 73: 493.CrossRefGoogle Scholar
  16. Roisin, M.P., Artola, A., Henry, J.P. and Rossier, J., 1983, Enkephalins are associated with adrenergic granules in bovine adrenal medulla, Neuroscience, 10: 83.CrossRefGoogle Scholar
  17. Snedecor, G.W. and Cochran, W.G., 1967, Statistical Methods, 6th edn. Ames: Iowa State College Press.Google Scholar
  18. Stine, S.M., Yang, H.-Y.T., and Costa, E., 1980, Release of enkephalin-like immunoreactive material from isolated bovine chromaffin cells, Neuronharmacoloav, 19: 683.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Jean Rossier
    • 1
  • E. Barrès
    • 1
  • A. Cupo
    • 2
  • A. V. Edwards
    • 3
  1. 1.Laboratoire de Physiologie NerveuseCNRSGif-su-YvetteFrance
  2. 2.Centre d’ImmunologieMarseille-LuminyFrance
  3. 3.The Physiological LaboratoryUniversity of CambridgeCambridgeEngland

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