In Situ Hybridization Study of Neurohypophysial Hormone mRNAS

  • Akihisa Urano
  • Susumu Hyodo
  • Moriyuki Sato


Neurohypophysial hormones, nonapeptides synthesized in hypothalamic magnocellular neurosecretory neurons, have been considered to function not only as neurohormones, but also as neurotransmitters or neuromodulators (Buijs, 1984; Jokura and Urano, 1987). In mammals, vasopressin is involved in osmotic and cardiovascular regulation, and oxytocin stimulates uterine contraction and milk ejection. However, there is no known role for oxytocin in males. Further, physiological roles of many other neurohypophysial hormones in lower vertebrates are not clear yet, mainly because of the lack of knowledge concerning secretory and synthetic activities of neurosecretory neurons in response to physiological stimuli. It is therefore probable that identification of stimuli which regulate synthetic activity of neurohypophysial hormones will help understanding of a biological significance for these hormones.


Water Deprivation Neurohypophysial Hormone Cross Species Hybridization Autoradiographic Signal Vasopressin mRNA 


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Akihisa Urano
    • 1
  • Susumu Hyodo
    • 1
  • Moriyuki Sato
    • 2
  1. 1.Department of Regulation BiologySaitama University UrawaSaitama 338Japan
  2. 2.Tokyo Research LaboratoriesKyowa Hakko Kogyo Co.Machida, Tokyo 194Japan

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