Developmental and Molecular Studies of Neurons that Express FMRFamide-Related Genes in Insects

  • Paul H. Taghert


Ernst and Berta Scharrer first demonstrated the glandular nature of magnocellular neurons more than 40 years ago. Since that time considerable effort has been made to prove the neuronal nature of neurosecretory cells (NSC) in the mammalian hypothamalmus and elsewhere: it has been shown for example, that these cells have active membrane properties (Copenhaver and Truman, 1986), that they have complex neuronal geometries (Taghert and Truman, 1982), and that they receive varied neuronal synaptic inputs (Jansen and Bos, 1984). Perhaps the sole distinction that can still be drawn between NSCs and conventional neurons is that, while the latter contact and synapse upon discrete cellular elements, NSCs instead form “blind”, synaptoid endings within structures termed Neurohaemal Organs (NHO). It is from such NSC terminations that various neuropeptides are released into the circulation and eventually act on cellular targets that are microns to meters away.


Growth Cone Neurosecretory Cell Segmental Ganglion Neurosecretory Neuron Active Membrane Property 
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  1. Carrol, L.S. Carrow, G.M. and Calabrese, R.L. 1986, Localization and resease of FMRFAMIDE-like immunoreactivity in the cerebral neurosecretory system of Manduca sexta., J. Exp. Biol., 126: 1.Google Scholar
  2. Carrow, G.M., Calabrese, R.L. and Williams, C.M., 1984, Architecture and physiology of insect cerebral nuurosecretory cells, J.Neurosci., 4: 1034.Google Scholar
  3. Copenhaver, P. and Truman, J.W., 1986, Control of neurosecretion in the moth Manduca sexta: physiological regulation of the eclosion hormone cells, J. Comp. Physiol. 158:445.Google Scholar
  4. Dellman, H.C., Sikora, K. and Castel, M., 1981, Fine structure of the rat supraoptic nucleus and neural lobe during pre-and post-natal development, in: “Neurosecretion: Molecules, Cells and Systems”, D.Farner and K. Lederis, eds., Plenum Press: New York, pp. 177–186.Google Scholar
  5. Evans, P.D. and Myers, C.M., 1986, Physiology of FMRFamide-related peptides in the neuromuscular junction of the locust, J. Exp. Biol. 126:403.Google Scholar
  6. Finlayson, L. and Osborne, M.P., 1969, Peripheral neurosecretory cells in the stick insect (Carausius morosus) and the blow-fly (Phormia terra novae) J. Insect Phvsiol. 14:1793.Google Scholar
  7. Goodman, C.S. and Heitler, W., J., 1979, Electrical properties of insect neurones with spiking and non-spiking somata: normal, axotomized and colchicine-treated neurones, J. Exp. Biol. 83: 95.Google Scholar
  8. Goodman, C.S. and Spitzer, N.C., 1979, Embryonic development of identified neurones: differentiation from neuroblast to neurone, Nature 280: 208.Google Scholar
  9. Hinks, C.F., 1976, Peripheral neurosecretory cells in some Lepidoptera, Cand. J. Zool. 53:1035.Google Scholar
  10. Jansen, R.F. and Bos, N.P.A., 1984, An identified neuron modulating the activity of the ovulation hormone producing caudo-dorsal cells of the pond snail I.vmnae staanalis.,J. Neurobiol. 15:161.Google Scholar
  11. Raabe, M., 1982, “Insect Neurohormones”, Plenum Press: New York.Google Scholar
  12. Schaeffer, M., Piciotto, M.R., Kreiner, T., Kaldany, R.R., Taussig, R. and Scheller, R.H., 1985, Aolvsia neurons express a gene encoding multiple FMRFamide neuropeptides, Cell, 41: 457.Google Scholar
  13. Taghert, P.H. and Truman,J.W., 1982, Identification of the bursicon-containing neurones in abdominal ganglia of the tobacco hornworm, Manduca sexta., J. Exo. Biol. 98:385.Google Scholar
  14. Taghert, P.H., and Goodman, C.S., 1984, Cell determination and differentiation of identified serotonin-immunoreactive neurons in grasshopper embryos, J. Neurosci. 4:989.Google Scholar
  15. Taghert, P.H., Bastiani, M.J., Ho, R.K. and Goodman, C.S., 1982, Guidance of pioneer growth cones: filopodial contacts and coupling revealed with an antibody to Lucifer Yellow, Dev. Biot. 94:391.Google Scholar
  16. Taghert, P.H., Carr, J.N., Wall, J.B. and Copenhaver, P.F., 1986, Embryonic formation of a simple neurosecretory nerve in the moth Manduca sexta. in: “Insect Neurochemistry and Neurophysiology”, A.B. Borkovec and D.B. Gelman, eds., The Humana Press: Clifton, N.J., pp. 143–172.Google Scholar
  17. Whitnall, M.H., Key,S., Ben-Barak, Y., Ozato, K. and Gainer, H., 1985, Neurophysin in the hypothalamo-neurohypophysial system. II. Immunocytochemical studies of the ontogeny of the oxytocinergic and vasopressinergic neurons, J. Neurosci. 5:98.Google Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Paul H. Taghert
    • 1
  1. 1.Department of Anatomy and NeurobiologyWashington University School of MedicineSaint LouisUSA

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