Neurosecretion pp 219-226 | Cite as

Intrinsic and Synaptic Factors Regulating Mammalian Magnocellular Neurosecretory Neuron Activity

  • Leo P. Renaud


The magnocellular oxytocin-synthesizing and vasopressin-synthesizing neurons of the hypothalamic supraoptic, paraventricular and accessory magnocellular nuclei are the classical mammalian neurosecretory neurons. Although research on these special endocrine neurons continues to provide increasing information on their morphology, peptide synthesis and neurosecretory mechanisms in the neurohypophysis, data has also been rapidly accumulating on their intrinsic membrane properties and synaptic inputs. The initial part of this chapter will report intracellular current- and voltage-clamp data which illustrate several intrinsic membrane conductances of supraoptic neurons magnocellular neurosecretory cells (magnocellular neurons); the second part will focus on a few samples of the synaptic inputs that can directly influence their activity.


Synaptic Input Supraoptic Nucleus Magnocellular Neuron Phasic Burst Antidromic Activation 


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Leo P. Renaud
    • 1
  1. 1.Neurosciences UnitMontreal General Hospital and McGill UniversityMontrealCanada

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