Anti-inflammatory Agents

  • Edward T. Knych


Descriptions of inflammation are found in the earliest medical records of civilization. The Greeks referred to it as phlogsis and the Romans as inflammatio. Cornelius Celsus (c. 30 b.c.e. to 38 c.e.) is generally given credit for describing the four cardinal signs of inflammation as rubor et tumor cum calore et dolore: redness and swelling with heat and pain. This nonspecific response of tissues is induced by diverse insults or stimuli. Most observations suggest that the inflammatory response is a beneficial reaction of tissues to injury, leading to removal of the inducing agent and repair of the injured tissue. However, if the stimulus persists, the process may become chronic and produce permanent tissue damage or inappropriate healing.


Adverse Side Effect Gastrointestinal Disturbance Reactive Oxygen Intermediate Central Nervous System Effect Glyceryl Ether 
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Suggested Readings

  1. Bonta IL, Bray MA, Parnham MJ (eds): The Pharmacology of Inflammation. New York, Elsevier, 1985.Google Scholar
  2. Calabrese LH, Rooney TW: The use of nonsteroidal anti-inflammatory drugs in sports. Physician Sportsmed 14: 89–97, 1986.Google Scholar
  3. Flower RJ, Moncada S, Vane JR: Analgesic-antipyretics and anti-inflammatory agents; drugs employed in the treatment of gout, in Gilman AG, Goodman LS, Rall TW, Murad F (eds): The Pharmacological Basis of Therapeutics, ed 7. New York, Macmillan, 1985, p 674.Google Scholar
  4. Ford-Hutchinson AW: Leukotrienes as mediators of inflammation. ISI Atlas of Science: Pharmacology 1: 25–28. 1987.Google Scholar
  5. Hart FD, Huskisson EC: Non-steroidal anti-inflammatory drugs. Drugs 27: 232–255, 1984.PubMedCrossRefGoogle Scholar
  6. Larson GL, Henson PM: Mediators of inflammation. Annu Rev Immunol 1: 335–359, 1983.CrossRefGoogle Scholar
  7. Lombardino JG (ed): Nonsteroidal Anti-inflammatory Drugs. New York, John Wiley and Sons, 1985.Google Scholar
  8. Lunec J, Griffiths HR, Blake DR: Oxygen radicals in inflammation. ISI Atlas of Science: Pharmacology 1: 45–48, 1987.Google Scholar
  9. Movat HZ: The Inflammatory Reaction. New York, Elsevier, 1985.Google Scholar

Copyright information

© Plenum Publishing Corporation 1988

Authors and Affiliations

  • Edward T. Knych
    • 1
  1. 1.Department of PharmacologyUniversity of Minnesota School of MedicineDuluthUSA

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